609342-46-3Relevant articles and documents
Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay
Ding, Yili,Hofstadler, Steven A.,Swayze, Eric E.,Risen, Lisa,Griffey, Richard H.
, p. 3409 - 3412 (2007/10/03)
A good starting point for the design of potent bactericidal compounds is the aminoglycoside paromomycin (1). The A-ring (shown in red) was replaced with a range of heterocycles. An ESIMS-based RNA-binding assay was used to screen the binding affinities of