60947-43-5

Basic information

• Product Name: 1-(4-CHLOROPHENYL)-2-NITROETHANE
• Synonyms: Benzene, 1-chloro-4-(2-nitroethyl)-
• CAS NO: 60947-43-5
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Product Categories: Miscellaneous
• Mol File: 60947-43-5.mol
• Article Data: 20

Chemical Properties

• Melting Point: 111-112 °C
• Boiling Point: 136 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.262±0.06 g/cm3(Predicted)
• PKA: 8.02±0.10(Predicted)
• CAS DataBase Reference: 1-(4-CHLOROPHENYL)-2-NITROETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROPHENYL)-2-NITROETHANE(60947-43-5)
• EPA Substance Registry System: 1-(4-CHLOROPHENYL)-2-NITROETHANE(60947-43-5)

Safety Data

• Hazardous Substances Data: 60947-43-5(Hazardous Substances Data)

Usage

Description

1-(4-Chlorophenyl)-2-nitroethane, a nitrostyrene derivative, is a chemical compound with the molecular formula C8H8ClNO2. It is a yellow crystalline solid with a molecular weight of 183.61 g/mol. 1-(4-CHLOROPHENYL)-2-NITROETHANE is often utilized in the synthesis of various pharmaceuticals and organic compounds, making it a valuable intermediate in the production of other chemicals.

Uses

Used in Pharmaceutical Industry:
1-(4-Chlorophenyl)-2-nitroethane is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs and medications, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-Chlorophenyl)-2-nitroethane is used as a starting material for the production of various agrochemicals. Its application in this field aids in the development of pesticides, herbicides, and other agricultural chemicals that are essential for maintaining crop health and productivity.

Upstream product

• 75-52-5 nitromethane 
• 71017-85-1 1-(4-chlorobenzyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 101671-01-6 1-nitro-2-(4-chlorophenyl)ethylene 
• 95-54-5 1,2-diamino-benzene 
• 101671-01-6 1-chloro-4-(2-nitro-1(Z)-ethenyl)benzene 
• 104-88-1 4-chlorobenzaldehyde 
• 89979-04-4 1-(4-chlorophenyl)-2-nitroethanol 
• 1875-88-3 2-(4-Chlorophenyl)ethanol 
• 6529-53-9 1-(2-bromoethyl)-4-chlorobenzene 

Downstream Products

• 60947-51-5 2-(4-Chloro-phenyl)-3-nitro-1,1-diphenyl-propan-1-ol 
• 60947-44-6 2-(4-Chlorphenyl)-1-nitrooctan 
• 4251-65-4 (4-chlorophenyl)acetaldehyde 
• 115170-91-7 1-Chloro-4-(2,2-dichloro-2-nitro-ethyl)-benzene 
• 156-41-2 4-chlorophenylethylamine 
• 70360-98-4 1-Chloro-4-(1-nitromethyl-2,2-diphenyl-vinyl)-benzene 
• 70360-99-5 1-Chloro-4-(2-methoxy-1-nitromethyl-2,2-diphenyl-ethyl)-benzene 
• 1261267-14-4 3-(4-chlorophenyl)-2-nitropropan-1-ol 
• 1017130-96-9 1,3-bis(4-chlorophenyl)-2-propanamine 
• 1273110-80-7 1,3-bis(4-chlorophenyl)-2-nitro-1-propene 
• 1273110-95-4 1-(4-methylthiophenyl)-3-(4-chlorophenyl)-2-nitro-1-propene 
• 4410-18-8 2-(4-chlorophenyl)acetaldehyde oxime 

Relevant articles and documents

Iridium-catalyzed highly chemoselective and efficient reduction of nitroalkenes to nitroalkanes in water

An iridium-catalyzed highly chemoselective and efficient transfer hydrogenation reduction of structurally diverse nitroalkenes was realized at very low catalyst loading (S/C = up to 10000 or 20?000), using formic acid or sodium formate as a traceless hydride donor in water. Excellent functionality tolerance is also observed. The turnover number and turnover frequency of the catalyst reach as high as 18?600 and 19?200 h-1, respectively. An inert atmosphere protection is not required. The reactivities of nitroalkenes are dependent on their substitution pattern, and the pH value is a key factor to accomplish the complete conversion and excellent chemoselectivity. Purification of products is achieved by simple extraction without column chromatography. The reduction procedure is facilely amplified to 10 g scale at 10?000 S/C ratio. The potential of this green reduction in enantioselective hydrogenation has been demonstrated.

Metal-Free Deoxygenation of Chiral Nitroalkanes: An Easy Entry to α-Substituted Enantiomerically Enriched Nitriles

A metal-free, mild and chemodivergent transformation involving nitroalkanes has been developed. Under optimized reaction conditions, in the presence of trichlorosilane and a tertiary amine, aliphatic nitroalkanes were selectively converted into amines or nitriles. Furthermore, when chiral β-substituted nitro compounds were reacted, the stereochemical integrity of the stereocenter was maintained and α-functionalized nitriles were obtained with no loss of enantiomeric excess. The methodology was successfully applied to the synthesis of chiral β-cyano esters, α-aryl alkylnitriles, and TBS-protected cyanohydrins, including direct precursors of four active pharmaceutical ingredients (ibuprofen, tembamide, aegeline and denopamine).

Nano-NiFe2O4 as an efficient catalyst for regio- and chemoselective transfer hydrogenation of olefins/alkynes and dehydrogenation of alcohols under Pd-/Ru-free conditions

Here, we have demonstrated the magnetic nano-NiFe2O4 catalyzed transfer hydrogenation of olefins/alkynes using isopropyl alcohol as a source of hydrogen under ligand/base/Pd-/Ru-metal-free conditions, and dehydrogenation of alcohols under oxidant-free conditions.