60964-09-2

Basic information

• Product Name: 2,6-DICHLORO-4-HYDROXYBENZALDEHYDE
• Synonyms: 2,6-Dichloro-4-hydroxybenzaldehyde;2,6-Dichloro-3-hydroxy-benzaldehyde
• CAS NO: 60964-09-2
• Molecular Formula: C₇H₄Cl₂O₂
• Molecular Weight: 191.01
• EINECS: 1312995-182-4
• Product Categories: Aromatic Aldehydes & Derivatives (substituted)
• Mol File: 60964-09-2.mol
• Article Data: 29

Chemical Properties

• Melting Point: 227-229°C
• Boiling Point: 295.8 °C at 760 mmHg
• Flash Point: 132.7 °C
• Appearance: /
• Density: 1.547 g/cm³
• Vapor Pressure: 0.000844mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.87±0.23(Predicted)
• Water Solubility: Insoluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2,6-DICHLORO-4-HYDROXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DICHLORO-4-HYDROXYBENZALDEHYDE(60964-09-2)
• EPA Substance Registry System: 2,6-DICHLORO-4-HYDROXYBENZALDEHYDE(60964-09-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 60964-09-2(Hazardous Substances Data)

Usage

Uses

As starting reagents proposed to use 4-hydroxy-2,6-dimethylbenzaldehyde and 2,6-dichloro-4-hydroxybenzaldehyde easily available by straightforward syntheses from commercial products.

InChI:InChI=1/C7H4Cl2O2/c8-6-1-4(11)2-7(9)5(6)3-10/h1-3,11H

Upstream product

• 67-66-3 chloroform 
• 591-35-5 3,5-dichlorophenol 
• 126663-61-4 1-<(tert-butyldimethylsilyl)oxy>-3,5-dichlorobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 82772-93-8 2,6-dichloro-4-methoxy-benzaldehyde 
• 616195-93-8 2,6-dichloro-4-triisopropylsilyloxy-benzaldehyde 
• 216257-25-9 3-chloro-5-[(triisopropylsilyl)oxy]phenyl chloride 
• 33719-74-3 3,5-dichloroanisole 
• 86111-47-9 (2,6-dichloro-4-methoxy-phenyl)-methanol 

Downstream Products

• 461031-79-8 4-(benzyloxy)-2,6-dichlorobenzaldehyde 
• 634192-53-3 3,5-dichloro-4-formyl-phenyl trifluoromethanesulfonate 
• 873111-12-7 2,6-dichloro-4-(2-phthalimidoethoxy)benzaldehyde 
• 873111-11-6 2,6-dichloro-4-(chloroacetoxy)benzaldehyde 
• 873111-49-0 5-[2,6-dichloro-4-(chloroacetoxy)phenyl]dipyrromethane 
• 873111-13-8 5-[2,6-dichloro-4-(2-phthalimidoethoxy)phenyl]dipyrromethane 
• 461031-80-1 4-benzyloxy-2,6-dichlorostyrene 
• 461031-82-3 (1S)-1-[4-(benzyloxy)-2,6-dichlorophenyl]-2-(tert-butyldimethylsilyl)oxy-1-ethylalcohol 
• 616195-97-2 methyl 2-(3,5-dichloro-4-formylphenoxy)acetate 
• 616196-07-7 2,6-dichloro-4-(2-hydroxyethoxy)benzaldehyde 
• 616196-01-1 (rac)-2,6-dichloro-4-(2,2-dimethyl-[1,3]-dioxolane-4-ylmethoxy) benzaldehyde 
• 616196-22-6 2,6-dichloro-4-[3-((tert-butyldimethylsilanyloxy))-2-(tert-butyldimethylsilanyloxymethyl)-propoxy)-benzaldehyde 
• 616196-00-0 dimethyl (3,5-dichloro-4-formylphenoxymethyl)phosphine oxide 
• 82772-93-8 2,6-dichloro-4-methoxy-benzaldehyde 

Relevant articles and documents

2-(2-ACRYLOYL-2,6-DIAZASPIRO[3.4]OCTAN-6-YL)-6-(1H-INDAZOL-4-YL)-BENZONITRILE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF G12C MUTANT KRAS PROTEIN FOR INHIBITING TUMOR METASTASIS

The present invention provides e.g. 2-(2-acryloyl-2,6- diazaspiro[3.4]octan-6-yl)-6-(lH-indazol-4-yl)-benzonitrile and e.g. 2-(2-acryloyl-2,7-diazaspiro[3.5]nonan-7-yl)-6-(1H-indazol-4-yl)- benzonitrile derivatives and related compounds of formula (I) as inhibitors of G12C mutant KRAS protein for treating tumor metastasis. The present description discloses exemplary compounds (e.g. pages 53 to 90; table 1; compounds I-1 to I-141), pharmacological data (e.g. page 125 to 128; table 2; example 1) and synthesis thereof (e.g. pages 129 to 143; examples 2 to 7). Exemplary compounds are e.g. 2-(2-acryloyl-2,6- diazaspiro[3.4]octan-6-yl)-6-(5-methyl-1H-indazol-4-yl)-4- morpholinobenzonitrile (example 2; compound I-1) and 6-(2- acryloyl-2,7-diazaspiro[3.5]nonan-7-yl)-3-methoxy-2-(5-methyl-1H- indazol-4-yl)-4-morpholinobenzonitrile (example 7; compound I-84).

DERIVATIVES OF SOBETIROME

Compounds are provided that function as thyromimetics, which compounds have utility for treating diseases such as neurodegenerative disorders. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation. Such compounds have the structure of Formula (I) as shown herein, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof.

Increasing Thyromimetic Potency through Halogen Substitution

Sobetirome is one of the most studied thyroid hormone receptor β (TRβ)-selective thyromimetics in the field due to its excellent selectivity and potency. A small structural change—replacing the 3,5-dimethyl groups of sobetirome with either chlorine or bro