609772-05-6

Basic information

• Product Name: 2-Butanol, 4-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]-, (2S)-
• CAS NO: 609772-05-6
• Molecular Formula: C26H27ClF3NO
• Molecular Weight: 461.955
• Mol File: 609772-05-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Butanol, 4-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanol, 4-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]-, (2S)-(609772-05-6)
• EPA Substance Registry System: 2-Butanol, 4-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]-, (2S)-(609772-05-6)

Safety Data

• Hazardous Substances Data: 609772-05-6(Hazardous Substances Data)

Upstream product

• 93118-03-7 2-chloro-3-trifluoromethylbenzaldehyde 
• 405911-35-5 N-(2,2-diphenylethyl)-N-(2-chloro-trifluoromethylbenzyl)amine 
• 82614-88-8 (S)-3-hydroxybutyl toluene-4-sulphonate 

Downstream Products

• 609772-04-5 (R)-2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-1-methyl-propoxy}-phenyl) acetic acid methyl ester 
• 847990-84-5 methanesulfonic acid (S)-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethylamino]-methyl-propyl ester 
• 847990-85-6 (2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[(R)-3-(1H-indol-4-yloxy)butyl]amine 
• 1193686-60-0 C₃₅H₃₅ClF₃NO₃ 

Relevant articles and documents

The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages

The liver X receptors (LXR) play a key role in cholesterol homeostasis and lipid metabolism. SAR studies around tertiary-amine lead molecule 2, an LXR full agonist, revealed that steric and conformational changes to the acetic acid and propanolamine groups produce dramatic effects on agonist efficacy and potency. The new analogs possess good functional activity, demonstrating the ability to upregulate LXR target genes, as well as promote cholesterol efflux in macrophages.

ACID AND ESTER COMPOUNDS AND METHODS OF USING THE SAME

Disclosed is a compound of having the formula (II-A), pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.