61002-03-7

Basic information

• Product Name: isopropyl 2-(4-(4-hydroxybenzoyl)phenoxy)-2-methylpropanoate
• Synonyms: isopropyl 2-(4-(4-hydroxybenzoyl)phenoxy)-2-methylpropanoate
• CAS NO: 61002-03-7
• Molecular Weight: 342.392
• Mol File: 61002-03-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: isopropyl 2-(4-(4-hydroxybenzoyl)phenoxy)-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: isopropyl 2-(4-(4-hydroxybenzoyl)phenoxy)-2-methylpropanoate(61002-03-7)
• EPA Substance Registry System: isopropyl 2-(4-(4-hydroxybenzoyl)phenoxy)-2-methylpropanoate(61002-03-7)

Safety Data

• Hazardous Substances Data: 61002-03-7(Hazardous Substances Data)

Upstream product

• 61002-04-8 2-Methyl-2-[4-(4-nitro-benzoyl)-phenoxy]-propionic acid isopropyl ester 
• 49562-28-9 fenofibrate 

Relevant articles and documents

Nucleophilic deoxyfluorination of phenols via aryl fluorosulfonate intermediates

This report describes a method for the deoxyfluorination of phenols with sulfuryl fluoride (SO2F2) and tetramethylammonium fluoride (NMe4F) via aryl fluorosulfonate (ArOFs) intermediates. We first demonstrate that the reaction of ArOFs with NMe4F proceeds under mild conditions (often at room temperature) to afford a broad range of electronically diverse and functional group-rich aryl fluoride products. This transformation was then translated to a one-pot conversion of phenols to aryl fluorides using the combination of SO2F2 and NMe4F. Ab initio calculations suggest that carbon-fluorine bond formation proceeds via a concerted transition state rather than a discrete Meisenheimer intermediate.

Synthesis of Phenols: Organophotoredox/Nickel Dual Catalytic Hydroxylation of Aryl Halides with Water

A highly effective hydroxylation reaction of aryl halides with water under synergistic organophotoredox and nickel catalysis is reported. The OH group of the resulting phenols originates from water, following deprotonation facilitated by an intramolecular base group on the ligand. Significantly, aryl bromides as well as less reactive aryl chlorides served as effective substrates to afford phenols with a wide range of functional groups. Without the need for a strong inorganic base or an expensive noble-metal catalyst, this process can be applied to the efficient preparation of diverse phenols and enables the hydroxylation of multifunctional pharmaceutically relevant aryl halides.