61021-52-1 Usage
Description
2-(1H-INDOL-3-YLSULFANYL)-ETHYLAMINE is an organic chemical compound characterized by the presence of an indole ring and a sulfanyl group attached to an ethylamine chain. This unique structure endows it with specific chemical properties that make it a valuable reactant in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
2-(1H-INDOL-3-YLSULFANYL)-ETHYLAMINE is used as a reactant in the preparation of cardiac-slowing amidines, which are potential antianginal agents. Its role in the synthesis process is crucial for developing new medications aimed at treating conditions related to the heart and cardiovascular system, such as angina. By contributing to the creation of these amidines, 2-(1H-INDOL-3-YLSULFANYL)-ETHYLAMINE plays a significant part in advancing pharmaceutical research and drug development for cardiac health.
Check Digit Verification of cas no
The CAS Registry Mumber 61021-52-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,0,2 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 61021-52:
(7*6)+(6*1)+(5*0)+(4*2)+(3*1)+(2*5)+(1*2)=71
71 % 10 = 1
So 61021-52-1 is a valid CAS Registry Number.
61021-52-1Relevant articles and documents
Cardiac-Slowing Amidines Containing the 3-Thioindole Group. Potential Antianginal Agents
Zelesko, Michael J.,McComsey, David F.,Hageman, William E.,Nortey, Samuel O.,Baker, Carol A.,Maryanoff, Bruce E.
, p. 230 - 237 (2007/10/02)
A series of 3-thioindolamidines (and 3-indolamidines) related to mixidine (1) was studied for cardiac-slowing properties, allowing the discovery of activity for prototype thioindole 2.Structure-activity relationships were explored, leading to many potent antitachycardic agents (6-9, 12, 13, 15-17, 20, 23, 24, 30, 34, 35, 45, and 47-49).Relative to 2, cardiac-slowing activity is enhanced by substitution of the indole nitrogen with small (C1-C3) saturated alkyl groups (6-9), unsaturated alkyl groups (12, 13, and 15-17), or a methoxyethyl group (20); replacement of the N-methyl group with alkyl (23) or phenyl groups (24); and extension of the ethylene bridge by two methylene units (34).Dethio (i.e., 3-indole) analogues of 2 with alkyl substitution on the indole nitrogen (47-49) have greater activity as well.Several potent compounds were also found to have minimal myocardial depression (6-9, 13, 45, and 47).Secondary pharmacological testing is reported for thioindoles 2, 6, 7, 9, and 28.
