6103-22-6Relevant articles and documents
Synthesis of the Hemoglobin-Conjugated Polymer Micelles by Thiol Michael Addition Reactions
Qi, Yanxin,Li, Taihang,Wang, Yupeng,Wei, Xing,Li, Bin,Chen, Xuesi,Xie, Zhigang,Jing, Xiabin,Huang, Yubin
, p. 906 - 913 (2016)
Amphiphilic triblock copolymers mPEG-b-PMAC-b-PCL are synthesized using methoxyl poly(ethylene glycol), cyclic carbonic ester monomer including acryloyl group, and ε-caprolactone. Copolymers are self-assembled into core–shell micelles in aqueous solution. Thiolated hemoglobin (Hb) is conjugated with micelles sufficiently through thiol Michael addition reaction to form hemoglobin nanoparticles (HbNs) with 200 nm in diameter. The conjugation of Hb onto the micelle surface is further confirmed by X-ray photoelectron spectroscopy. Feeding ratio of copolymer micelles to Hb at 1:3 would lead to the highest hemoglobin loading efficiency 36.7 wt%. The UV results demonstrate that the gas transporting capacity of HbNs is well remained after Hb is conjugated with polymeric micelles. Furthermore, the obtained HbNs have no obvious detrimental effects on blood components in vitro. This system may thus have great potential as one of the candidates to be developed as oxygen carriers and provide a reference for the modification of protein drugs. (Figure presented.) .
An investigation of siloxane cross-linked hydroxyapatite-gelatin/copolymer composites for potential orthopedic applications
Dyke, Jason Christopher,Knight, Kelly Jane,Zhou, Huaxing,Chiu, Chi-Kai,Ko, Ching-Chang,You, Wei
, p. 22888 - 22898 (2012)
Causes of bone deficiency are numerous, but biomimetic alloplastic grafts provide an alternative to repair tissue naturally. Previously, a hydroxyapatite-gelatin modified siloxane (HAp-Gemosil) composite was prepared by cross-linking N,N'-bis[(3-trimethoxysilyl)propyl]ethylene diamine (enTMOS) around the HAp-gel nanocomposite particles, to mimic the natural composition and properties of bone. However, the tensile strength remained too low for many orthopedic applications. It was hypothesized that incorporating a polymer chain into the composite could help improve long range interaction. Furthermore, designing this polymer to interact with the enTMOS siloxane cross-linked matrix would provide improved adhesion between the polymer and the ceramic composite, and improve mechanical properties. To this end, copolymers of l-lactide (LLA), and a novel alkyne derivatized trimethylene carbonate, propargyl carbonate (PC), were synthesized. Incorporation of PC during copolymerization affects properties of copolymers such as molecular weight, Tg, and %PC incorporation. More importantly, PC monomers bear a synthetic handle, allowing copolymers to undergo post-polymerization functionalization with graft monomers to specifically tailor the properties of the final composite. For our investigation, P(LLA-co-PC) copolymers were functionalized by an azido-silane (AS) via copper catalyzed azide-alkyne cycloaddition (CuAAC) through terminal alkyne on PC monomers. The new functionalized polymer, P(LLA-co-PC)(AS) was blended with HAp-Gemosil, with the azido-silane linking the copolymer to the silsesquioxane matrix within the final composite. These HAp-Gemosil-P(LLA-co-PC) (AS) composites were subjected to mechanical and biological testing, and the results were compared with those from the HAp-Gemosil composites. This study revealed that incorporating a cross-linkable polymer served to increase the flexural strength of the composite by 50%, while maintaining the biocompatibility of HAp-Gemosil ceramics.
MANUFACTURING METHOD OF TRIMETHYLENE CARBONATE DERIVATIVE
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Paragraph 0031; 0032, (2019/10/01)
PROBLEM TO BE SOLVED: To enable easily synthesizing a trimethylene carbonate derivative containing no ester bond. SOLUTION: The manufacturing method of a trimethylene carbonate derivative having a process for obtaining a compound A represented by the following formula (2) by protecting hydroxyl groups at 2 locations of trimethylolalkane represented by the following formula (1) by a protection agent at same time, a process for obtaining a compound B represented by the formula (3) and having 2 hydroxyl groups by reducing the compound A by a reductant and deprotecting only one of the 2 locations, a process for obtaining a trimethylene carbonate derivative represented by the formula (4) by carbonylating 2 hydroxyl groups of the compound B. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
Novel synthesis method of ester free trimethylene carbonate derivatives
Nobuoka, Hiroaki,Ajiro, Hiroharu
, p. 164 - 170 (2019/01/04)
Ester free poly(trimethylene carbonate) (PTMC) derivatives show biocompatibility and biodegradability and do not generate any acidic compounds after decomposition. Their syntheses methods are limited however, hampering their material application. Herein, we established a novel synthesis route of ester free trimethylene carbonate (TMC) derivatives. The novel synthesis route was described using six aldehydes and one ketone as starting compounds. The key reaction is the selective deprotection from two protected hydroxyl groups in the cyclic acetal structure by diisobutylaluminium hydride. This novel synthesis route means that it is possible to convert aldehyde group to ether groups in the side chain of TMC. Conventionally, only a substituent derived from a primary alcohol was introduced into the side chain. We therefore succeeded in decreasing the number of reaction steps from five to three, compared with the conventional route. Furthermore, the development of a novel synthesis route enabled the introduction of substituents derived from secondary alcohols, anticipating the creation of further types of ester free TMC derivatives.
