61043-10-5

Basic information

• Product Name: pyridine-2-carbaldehyde thiosemicarbazone
• Synonyms: (2E)-2-(Pyridin-2-ylmethylene)hydrazinecarbothioamide; 2-(2-pyridylmethylidene)hydrazine-1-carbothioamide; 2-pyridinecarboxaldehyde, 2-[(1Z)-aminomercaptomethylene]hydrazone; hydrazinecarbothioamide, 2-(2-pyridinylmethylene)-, (2E)-; N'-(pyridin-2-ylmethylene)carbamohydrazonothioic acid; N'-[(E)-pyridin-2-ylmethylidene]carbamohydrazonothioic acid
• CAS NO: 61043-10-5
• Molecular Formula: C₇H₈N₄S
• Molecular Weight: 180.2302
• Mol File: 61043-10-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 346.5°C at 760 mmHg
• Flash Point: 163.3°C
• Density: 1.32g/cm³
• Vapor Pressure: 5.74E-05mmHg at 25°C
• Refractive Index: 1.665
• CAS DataBase Reference: pyridine-2-carbaldehyde thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: pyridine-2-carbaldehyde thiosemicarbazone(61043-10-5)
• EPA Substance Registry System: pyridine-2-carbaldehyde thiosemicarbazone(61043-10-5)

Safety Data

• Hazardous Substances Data: 61043-10-5(Hazardous Substances Data)

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 412318-66-2 (2-Formylpyridin-3-yl)carbamic acid 2-bis(2-trimethylsilylethyl)phosphonooxy-5-chlorobenzyl ester 
• 79-19-6 thiosemicarbazide 
• 61043-11-6 2-pyridylcarbaldehyde (Z)-thiosemicarbazone 

Downstream Products

• 61043-11-6 2-pyridylcarbaldehyde (Z)-thiosemicarbazone 
• 5711-72-8 2-amino-5-(pyridin-2-yl)-1,3,4-oxadiazole 
• 16085-74-8 2-(2-(pyridin-2-ylmethylene)hydrazinyl)-4-(3-nitrophenyl)-1,3-thiazole 

Relevant articles and documents

Elucidation of the structure of the antineoplastic agents, 2 formylpyridine and 1 formylisoquinoline thiosemicarbazones

The geometrical isomers of the antineoplastic agents 2 formylpyridine and 1 formylisoquinoline thiosemicarbazones were synthesized and their structure was studied by spectroscopic methods. It was found that the compounds previously described in the litera

4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis

A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substituents were linked to N1 of the hydrazone in order to establish robust structure–activity relationships. The results of the biological testing demonstrated that the presence of the hydrazothiazole nucleus bearing at C4 a phenyl ring functionalised at the meta position with a nitro group represents an important pharmacophoric feature to obtain selective and reversible human MAO-B inhibition for the treatment of neurodegenerative disorders. In addition, the most potent and selective MAO-B inhibitors were evaluated in silico as potential cholinesterase (AChE/BuChE) inhibitors and in vitro for antioxidant activities. The results obtained from molecular modelling studies provided insight into the multiple interactions and structural requirements for the reported MAO inhibitory properties.

2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: Structural design, synthesis and pharmacological evaluation

The present work reports on the synthesis, anti-Trypanosoma cruzi activities and docking studies of a novel series of 2-(pyridin-2-yl)-1,3- thiazoles derived from 2-pyridine thiosemicarbazone. The majority of these compounds are potent cruzain inhibitors