6108-05-0

Basic information

• Product Name: Linocaine hydrochloride
• Synonyms: Lignocaine monohydrate hydrochloride, Xylocaine monohydrate hydrochloride, 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide monohydrate hydrochloride;2-Dimethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride;Diethylamino-2,6-dimethylacetanilide hydrochloride;Lidocaine hydrochloride monohydrate,2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate, Lignocaine hydrochloride monohydrate, Xylocaine hydrochloride monohydrate;Linocaine hydrochlor;2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride hydrate;Linocaine hydrochloride hydrate;Lidocaine Hydrochloride BP98 USP24
• CAS NO: 6108-05-0
• Molecular Formula: C14H25ClN2O2
• Molecular Weight: 288.81
• EINECS: 200-803-8
• Product Categories: Sodium channel;hydrochloride . hydrate;Other APIs;API;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 6108-05-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 75-79℃
• Boiling Point: 350.8 °C at 760 mmHg
• Flash Point: 166 °C
• Appearance: white/solid
• Vapor Pressure: 4.28E-05mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble
• Water Solubility: Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether.
• CAS DataBase Reference: Linocaine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Linocaine hydrochloride(6108-05-0)
• EPA Substance Registry System: Linocaine hydrochloride(6108-05-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: AN7700000
• TSCA: Yes
• HazardClass: 6.1
• Hazardous Substances Data: 6108-05-0(Hazardous Substances Data)

Usage

Description

Lidocaine hydrochloride, also known as lidocaine monohydrate, is a white or almost white crystalline powder that serves as a pharmaceutical secondary standard for quality control in pharmaceutical laboratories and manufacturing. It is a fast voltage-gated sodium channel blocker with long-acting, membrane-stabilizing properties against ventricular arrhythmia and was originally developed as a local anesthetic.

Uses

Used in Pharmaceutical Industry:
Lidocaine hydrochloride is used as a local anesthetic for numbing specific areas of the body during minor surgical procedures or diagnostic tests. It is also used as an antiarrhythmic agent, specifically in the class IB category, to help regulate abnormal heart rhythms.
Used in Medical Applications:
Lidocaine hydrochloride is used as a Na+ channel blocker in local anesthesia and heart rhythm disorders, helping to stabilize the heart's electrical activity and prevent life-threatening arrhythmias.
Brand Names:
Some of the brand names for lidocaine hydrochloride include Alpha caine Hydrochloride (Carlisle), Anestacon (Polymedica), Laryng-O-Jet (International Medication), Lidocaton (Phar maton), Lidopen (Meridian), Xylocaine (Abraxis), and Xylocaine (AstraZeneca and Dentsply).

Contact allergens

Linocaine hydrochloride is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic.

InChI:InChI=1/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2