61081-34-3

Basic information

• Product Name: 1-[(methylsulfonyl)methyl]-4-nitrobenzene
• Synonyms: 1-[(methylsulfonyl)methyl]-4-nitrobenzene;1-(Methanesulfonylmethyl)-4-Nitrobenzene;1-(Methanesulfonylmethyl)-4-Nitrobenzene(WX682916)
• CAS NO: 61081-34-3
• Molecular Formula: C₈H₉NO₄S
• Molecular Weight: 215.22636
• Mol File: 61081-34-3.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 459.8°Cat760mmHg
• Flash Point: 231.9°C
• Appearance: /
• Density: 1.387g/cm³
• Vapor Pressure: 3.37E-08mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 1-[(methylsulfonyl)methyl]-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(methylsulfonyl)methyl]-4-nitrobenzene(61081-34-3)
• EPA Substance Registry System: 1-[(methylsulfonyl)methyl]-4-nitrobenzene(61081-34-3)

Safety Data

• Hazardous Substances Data: 61081-34-3(Hazardous Substances Data)

Usage

General Description

1-[(methylsulfonyl)methyl]-4-nitrobenzene, also known as Dibenzosulfone, is a chemical compound with the molecular formula C8H9NO4S. It is a yellow crystalline solid that is used in the production of dyes, pigments, and pharmaceuticals. 1-[(methylsulfonyl)methyl]-4-nitrobenzene is also used as an intermediate in the synthesis of various organic compounds. It is considered to be moderately toxic and an irritant to the skin, eyes, and respiratory system, and should be handled with caution. Additionally,

InChI:InChI=1/C8H9NO4S/c1-14(12,13)6-7-2-4-8(5-3-7)9(10)11/h2-5H,6H2,1H3

Upstream product

• 20277-69-4 sodium methansulfinate 
• 100-14-1 4-nitrobenzyl chloride 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 51392-53-1 4-nitrobenzyl methyl sulfide 
• 100-39-0 benzyl bromide 
• 77-78-1 dimethyl sulfate 
• 3112-90-1 benzyl-methyl sulfone 
• 7697-37-2 nitric acid 
• 619-75-0 1-dibromomethyl-4-nitro-benzene 
• 2386-57-4 methanesulfonic acid sodium salt 
• 104-03-0 4-nitrobenzeneacetic acid 
• 619-73-8 4-nitrobenzyl chloride 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 24176-70-3 4-[(methylsulfonyl)methyl]aniline 
• 5440-67-5 2-(4-nitrobenzyl)-2-nitropropane 
• 62-23-7 4-nitro-benzoic acid 
• 82720-39-6 Acridin-9-yl-(4-methanesulfonylmethyl-phenyl)-amine; hydrochloride 
• 635702-62-4 1-[1-methyl-1-(methylsulfonyl)ethyl]-4-nitrobenzene 
• 120383-85-9 1-(cyclopropylmethyl)-4-nitrobenzene 

Relevant articles and documents

NAMPT MODULATORS

Provided are compounds of Formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.

Copper-Mediated Decarboxylative Sulfonylation of Arylacetic Acids with Sodium Sulfinates

Herein, we present a copper-mediated decarboxylative sulfonylation of arylacetic acids with sodium sulfinates that provides viable access to sulfone compounds. This protocol features readily available feedstocks, simple operations, high regioselectivities, and moderate to good yields. The newly obtained products could be converted to other useful compounds. Importantly, the products and their derivatives exhibited potent antitumor activities in vitro, which were tested by MTT assay.

Bromine structural domain inhibitor compound and application thereof

The invention relates to a bromine structural domain inhibitor and provides a compound shown in a general formula I, pharmaceutical salt, an enantiomer, a diastereoisomer, an atropisomer, racemate, apolymorphic substance and solvate of the compound or an isotope labelled compound (including a deuterium substituted compound), a preparation method of the compound, pharmaceutical composition containing the compound and an application of the above components in pharmaceuticals.