611212-55-6

Basic information

• Product Name: (R)-3-benzyloxycarbonyl-2-pentylpropanoic acid
• Synonyms: (R)-3-benzyloxycarbonyl-2-pentylpropanoic acid
• CAS NO: 611212-55-6
• Molecular Weight: 278.348
• Mol File: 611212-55-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3-benzyloxycarbonyl-2-pentylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-benzyloxycarbonyl-2-pentylpropanoic acid(611212-55-6)
• EPA Substance Registry System: (R)-3-benzyloxycarbonyl-2-pentylpropanoic acid(611212-55-6)

Safety Data

• Hazardous Substances Data: 611212-55-6(Hazardous Substances Data)

Upstream product

• 1035609-58-5 benzyl 4-[(S)-4-benzyl-2-oxooxazolidin-3-yl]-3-pentyl-4-oxobutanoate 

Downstream Products

• 1035609-97-2 N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]glycine methyl ester 
• 1035609-99-4 N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]-L-alanine methyl ester 
• 1035610-01-5 N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]-L-valine methyl ester 
• 1035609-77-8 N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]-L-leucine methyl ester 
• 1035610-05-9 N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]-L-phenylalanine methyl ester 
• 1035610-03-7 N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]-L-tert-leucine methyl ester 

Relevant articles and documents

Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin

A series of hybrid compounds of bestatin (1) and actinonin (3), which promote degradation of cellular inhibitor of apoptosis protein 1 (cIAP1), were designed and synthesized. Structure-activity relationship studies indicated that absolute configuration, hydrophobicity at the α-position of the internal amide carbonyl group, and the presence of a small substituent at the α-position of the ester group are important factors for the expression of potent cIAP1 degradation-promoting activity. HAB-5A (30b) showed the most potent activity (IC50 = 0.53 μM) among the compounds prepared.