611218-31-6Relevant articles and documents
SUBSTITUTED PYRANO [2, 3 - B] PYRIDINE DERIVATIVES AS CANNABINOID -1 RECEPTOR MODULATORS
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Page/Page column 75-76, (2008/12/07)
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present in
Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists
Debenham, John S.,Madsen-Duggan, Christina B.,Walsh, Thomas F.,Wang, Junying,Tong, Xinchun,Doss, George A.,Lao, Julie,Fong, Tung M.,Schaeffer, Marie-Therese,Xiao, Jing Chen,Huang, Cathy R.-R. C.,Shen, Chun-Pyn,Feng, Yue,Marsh, Donald J.,Stribling, D. Sloan,Shearman, Lauren P.,Strack, Alison M.,MacIntyre, D. Euan,Van Der Ploeg, Lex H. T.,Goulet, Mark T.
, p. 681 - 685 (2007/10/03)
Synthesis, SAR, and binding affinities are described for a new class of 1,8-naphthyridinone CB1 receptor specific inverse agonists. Food intake, knockout mouse, and pharmacokinetic evaluation of 14 indicate that this compound is an effective orally active
Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists
Meurer, Laura C.,Finke, Paul E.,Mills, Sander G.,Walsh, Thomas F.,Toupence, Richard B.,Goulet, Mark T.,Wang, Junying,Tong, Xinchun,Fong, Tung M.,Lao, Julie,Schaeffer, Marie-Therese,Chen, Jing,Shen, Chun-Pyn,Sloan Stribling,Shearman, Lauren P.,Strack, Alison M.,Van Der Ploeg, Lex H.T.
, p. 645 - 651 (2007/10/03)
Structure-activity relationship studies for two series of 2-benzyloxy-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyridines having either a 3-cyano or 3-carboxamide moiety resulted in the preparation of the 2-(3,4-difluorobenzyloxy)-3-nitrile analog 10d and