61123-41-9Relevant articles and documents
Tungsten-Catalyzed Transamidation of Tertiary Alkyl Amides
Feng, Fang-Fang,Liu, Xuan-Yu,Cheung, Chi Wai,Ma, Jun-An
, p. 7070 - 7079 (2021/06/30)
Transamidation has recently emerged as a straightforward and convenient means to diversify amides. However, the kinetically and thermodynamically demanding transamidation of notoriously robust, fully alkyl-substituted tertiary amides still remains a longstanding challenge. Here, we describe a method for the activation of tertiary alkyl amides to streamline transamidation using simple tungsten(VI) chloride as a catalyst and chlorotrimethylsilane as an additive. The highly electrophilic and oxophilic tungsten catalyst enables the selective scission of a C-N bond of tertiary alkyl amides to effect transamidation of a myriad of structurally and electronically diverse tertiary alkyl amides and amines. Mechanistic study implies that the synergistic effect of the catalyst and the additive could pronouncedly induce the nucleophilic acyl substitution of tertiary alkyl amide with amine to realize transamidation.
SYNTHESIS AND PROPERTIES OF SOME N,N,-DIALKYLAMIDES AS NEW EXTRACTANTS.
Al-Jallo,Hussain,Mansoor,Sameh,Al-Saidi
, p. 479 - 481 (2007/10/02)
Forty-seven new N,N-dialkylamides were prepared and their physical and spectral data are tabulated. The solubility of amides 1-47 in organic and aqueous solvents was tested and the results showed that as the amides are freely soluble in organic solvents t
