61150-59-2

Basic information

• Product Name: 2-Bromo-4-fluorophenylacetic acid
• Synonyms: 2-Bromo-4-fluorophenylacetic acid;2-(3-bromo-4-fluorophenyl)acetic acid;Acid 2-bromo-4-fluoro
• CAS NO: 61150-59-2
• Molecular Formula: C₈H₆BrFO₂
• Molecular Weight: 233.03
• Product Categories: Fluorobenzene;Phenylacetic acid
• Mol File: 61150-59-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 108-111°C
• Boiling Point: 320.3 °C at 760 mmHg
• Flash Point: 147.5 °C
• Appearance: /
• Density: 1.697 g/cm³
• Vapor Pressure: 0.000133mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.02±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-4-fluorophenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-fluorophenylacetic acid(61150-59-2)
• EPA Substance Registry System: 2-Bromo-4-fluorophenylacetic acid(61150-59-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 61150-59-2(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-fluorophenylacetic acid is a chemical compound that belongs to the phenylacetic acid family. This relatively niche compound has much potential in relation to chemical synthesis, as it can serve as a useful intermediate for the production of various pharmaceuticals, agrochemicals and other organic compounds. It features a bromine atom and a fluorine atom attached to a phenyl ring, along with an acetic acid group. Its precise molecular formula is C8H6BrFO2. The fluorine and bromine contribute unique properties that can be leveraged for chemical reactions. As with other chemicals, safe handling practices are required due to potential hazards associated with exposure or misuse.

InChI:InChI=1/C8H6BrFO2/c9-7-4-6(10)2-1-5(7)3-8(11)12/h1-2,4H,3H2,(H,11,12)

Upstream product

• 61150-58-1 2-(2-bromo-4-fluorophenyl)acetonitrile 
• 1422-53-3 2-bromo-4-fluorotoluene 
• 61150-57-0 2-bromo-4-fluorobenzyl bromide 

Downstream Products

• 65999-41-9 2-(2-bromo-4-fluorophenyl)acetamide 
• 61150-66-1 2-(4-chloro-3-methoxyphenylthio)-4-fluorophenylacetic acid 
• 1086601-89-9 (2-bromo-4-fluoro-phenyl)-acetyl chloride 
• 68600-06-6 <4-fluoro-2-(4-isopropylphenylthio)phenyl>acetic acid 
• 61150-30-9 1-(8-chloro-3-fluoro-7-methoxy-dibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine 
• 951774-92-8 C₁₂H₁₃BrFNO 
• 949168-33-6 1-amino-3-(2-bromo-4-fluorophenyl)piperidin-2-one 
• 1350840-09-3 2-(2-bromo-4-fluorophenyl)-N-methoxyacetamide 
• 1012879-09-2 2-(2-bromo-4-fluoro-5-nitrophenyl)acetic acid 
• 1012879-10-5 ethyl 2-(2-bromo-4-fluoro-5-nitrophenyl)acetate 
• 1442471-26-2 ethyl 2-(5-amino-2-bromo-4-fluorophenyl)acetate 
• 1442470-69-0 3-(5-amino-2-bromo-4-fluorophenyl)-1-ethyl-7-(2-methoxyethylamino)-1,6-naphthyridin-2(1H)-one 
• 1442470-71-4 3-(5-amino-2-bromo-4-fluorophenyl)-1-ethyl-7-(2-(methylthio)ethylamino)-1,6-naphthyridin-2(1H)-one 
• 1442470-72-5 7-(4-methoxybenzylamino)-3-(5-amino-2-bromo-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one 

Relevant articles and documents

Chiral Magnesium Bisphosphate-Catalyzed Asymmetric Double C(sp3)-H Bond Functionalization Based on Sequential Hydride Shift/Cyclization Process

Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp3)-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp3)-H bond functionalization: (1) a highly enantio- and diastereoselective C(sp3)-H bond functionalization by chiral magnesium bisphosphate (first [1,5]-hydride shift), and (2) a highly diastereoselective C(sp3)-H bond functionalization by an achiral catalyst (Yb(OTf)3, second [1,5]-hydride shift).

Synthesis of N-alkoxyindol-2-ones by copper-catalyzed intramolecular N-arylation of hydroxamates

The first example of copper-catalyzed intramolecular N-arylation of hydroxamic acid derivatives is presented. Based on this transformation a new method for the synthesis of N-alkoxyindol-2-ones from 2-(2-bromoaryl) acetylhydroxamates has been developed. T