61172-66-5

Basic information

• Product Name: N-Boc-2-propargyl-glycine
• Synonyms: 2-(Boc-amino)-4-pentynoic acid;N-Boc-2-propargyl-glycine;2-((tert-butoxycarbonyl)aMino)pent-4-ynoic acid;2-(tert-butoxycarbonyl)pent-4-ynoic acid;4-Pentynoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-;Boc-RS-2-Propynylglycine
• CAS NO: 61172-66-5
• Molecular Formula: C₁₀H₁₅NO₄
• Molecular Weight: 213.2304
• EINECS: -0
• Mol File: 61172-66-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-Boc-2-propargyl-glycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-2-propargyl-glycine(61172-66-5)
• EPA Substance Registry System: N-Boc-2-propargyl-glycine(61172-66-5)

Safety Data

• Hazardous Substances Data: 61172-66-5(Hazardous Substances Data)

Usage

General Description

N-Boc-2-propargyl-glycine is a chemical compound with the molecular formula C10H15NO4. It is a derivative of glycine, an essential amino acid, and contains a Boc (tert-butoxycarbonyl) protecting group and a propargyl functional group. N-Boc-2-propargyl-glycine is commonly used in organic synthesis as a building block for the preparation of various biologically active molecules and pharmaceuticals. It is a versatile intermediate that is utilized in the development of new drugs and materials. N-Boc-2-propargyl-glycine is also known for its potential applications in the field of medicinal chemistry and drug discovery. Overall, this compound has a significant role in the advancement of chemical and pharmaceutical research.

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 23235-01-0 L-Propargylglycine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 23235-01-0 (R)-2-aminopent-4-ynoic acid 

Downstream Products

• 71460-02-1 methyl (2S)-2-(tert-butoxycarbonylamino)pent-4-ynoate 
• 1026127-32-1 (S)-2-tert-Butoxycarbonylamino-5-(2-fluoro-phenyl)-pent-4-ynoic acid 

Relevant articles and documents

D-ALA-D-ALA-BASED DIPEPTIDES AS TOOLS FOR IMAGING PEPTIDOGLYCAN BIOSYNTHESIS

Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria using modified dipeptides containing a bioorthogonal tag and applying novel post-labeling methods to label the bioorthogonal tag. The resultant, labeled peptidoglycan structures are amenable for identifying bacteria by microscopic visualization.

N6-(2-(R)-propargylglycyl)lysine as a clickable pyrrolysine mimic

Clickable copycat! Readily available dipeptide d-Pra-ε-Lys is identified using a modified fluorescence protein assay as a highly efficient clickable pyrrolysine mimic. It is shown to incorporate into calmodulin in high yield to provide a handle for labeling with anazide-containing coumarin.

Synthesis, properties and crystal structure of the tripeptide boc-L-prolyl-L-propargylglycyl-glycine methylester

Propargylglycine, as a powerful inhibitor of microbial growth, was built into a protected tripeptide with the sequence Pro-Pra-Gly. The peptide was employed to study its effects on the activity of prolyl 4-hydroxylase and the collagen biosynthesis. The Boc-protected tripeptide methylester was identified by mass spectrometry and NMR spectroscopy and its crystal structure was established by X-ray diffraction analysis.