61198-49-0

Basic information

• Product Name: 2H-Pyran-2-one, tetrahydro-4-phenyl-, (4S)-
• Synonyms: 2H-Pyran-2-one, tetrahydro-4-phenyl-, (4S)-
• CAS NO: 61198-49-0
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Mol File: 61198-49-0.mol
• Article Data: 72

Chemical Properties

• Boiling Point: 340.8±31.0 °C(Predicted)
• Density: 1.113±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2H-Pyran-2-one, tetrahydro-4-phenyl-, (4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-2-one, tetrahydro-4-phenyl-, (4S)-(61198-49-0)
• EPA Substance Registry System: 2H-Pyran-2-one, tetrahydro-4-phenyl-, (4S)-(61198-49-0)

Safety Data

• Hazardous Substances Data: 61198-49-0(Hazardous Substances Data)

Upstream product

• 4160-80-9 3-phenylglutaric acid anhydride 
• 128951-26-8 6-Methylsulfanyl-4-phenyl-pyran-2-one 
• 3393-45-1 5,6-dihydro-pyran-2-one 
• 98-80-6 phenylboronic acid 
• 829-27-6 3-phenylpentane-1,5-diol 
• 4165-96-2 3-phenylglutaric acid 
• 55951-74-1 diethyl 3-phenylpentanedioate 
• 64145-51-3 3-phenylcyclopentanone 
• 3174-83-2 3-phenylbut-3-en-1-ol 
• 879-59-4 4-phenyl-5,6-dihydro-2H-pyran-2-one 
• 1392283-27-0 C₁₃H₁₄O₂ 
• 143-66-8 sodium tetraphenyl borate 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 19006-47-4 dimethyl 3-phenylpentanedioate 

Downstream Products

• 114199-69-8 2-ethyl-3-phenyl-5-pentanolide 
• 114199-68-7 2-methyl-3-phenyl-5-pentanolide 
• 71302-21-1 (4R)-4-phenyltetrahydro-2H-pyran-2-one 
• 1123193-24-7 5-hydroxy-3-phenylpentanoic acid hydrazide 
• 138662-94-9 3(S)-azido-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(S)-phenyl-1-piperidineacetamide 
• 138571-14-9 3(S)-azido-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide 
• 138571-15-0 3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide 
• 138662-95-0 3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(S)-phenyl-1-piperidineacetamide 
• 138662-92-7 3-<4-(1,3-dioxolan-2-yl)-1-oxo-3(S)-phenyl-2(S)-azidobutyl>-4(S)-(phenylmethyl)-2-oxazolidinone 
• 138571-12-7 3-<4-(1,3-dioxolan-2-yl)-1-oxo-3(R)-phenyl-2(S)-azidobutyl>-4(S)-(phenylmethyl)-2-oxazolidinone 
• 138571-30-9 3-<4-(1,3-dioxolan-2-yl)-1-oxo-3(R)-phenylbutyl>-4(S)-(phenylmethyl)-2-oxazolidinone 
• 138571-11-6 3-<4-(1,3-dioxolan-2-yl)-1-oxo-3(S)-phenylbutyl>-4(S)-(phenylmethyl)-2-oxazolidinone 
• 138662-93-8 3-<2(S)-azido-1,5-dioxo-3(S)-phenylpentyl>-4(S)-phenylmethyl-2-oxazolidinone 
• 138571-13-8 3-<2(S)-azido-1,5-dioxo-3(R)-phenylpentyl>-4(S)-phenylmethyl-2-oxazolidinone 

Relevant articles and documents

Asymmetric Synthesis of Chiral Bicyclo[2.2.1]hepta-2,5-diene Ligands through Rhodium-Catalyzed Asymmetric Arylative Bis-cyclization of a 1,6-Enyne

A series of novel chiral diene ligands (1R,4S)-L1, which are based on the bicyclo[2.2.1]heptadiene skeleton and are substituted with methyl and an ester group at the bridgehead carbons, were synthesized through rhodium-catalyzed asymmetric arylative bis-c

The mutagenesis of a single site for enhancing or reversing the enantio- or regiopreference of cyclohexanone monooxygenases

The mutagenesis of a "second sphere"switch residue of CHMOAcineto could control its enantio- and regiopreference. Replacing phenylalanine (F) at position 277 of CHMOAcineto into larger tryptophan (W) enabled a significant enhancement of enantio- or regioselectivity toward structurally diverse substrates, moreover, a complete reversal of enantio- or regiopreference was realized by mutating F277 into a range of smaller amino acids (A/C/D/E/G/H/I/K/L/M/N/P/Q/R/S/T/V).

Control of Enantioselectivity in Rhodium(I) Catalysis by Planar Chiral Dibenzo[a,e]cyclooctatetraenes

Planar chiral 5,11-disubstiuted dibenzo[a,e]cyclo-octatetraenes (dbCOTs) have been developed as the first useful chiral homologs to dbCOT-ligands for asymmetric applications. Methods enabling the preparation of such compounds on a gram-scale in enantiomerically pure form are described. Evaluated as ligands in rhodium(I)-catalyzed 1,4- and 1,2-arylation reactions, tertiary and quarternary stereogenic centers were formed with excellent yields and selectivities of up to >99 % ee. A catalytic asymmetric synthesis of a key cyclization precursor to (?)-penifulvin A highlights the system in an applied context.