612494-86-7 Usage
Description
7-BROMO-2,3-DIHYDROPYRANO[2,3-B]QUINOLINE, also known as 7-Bromo-3,4,10,10a-tetrahydro-2H-pyrano[2,3-b]quinoline, is a chemical compound that serves as a reagent in the synthesis of pharmaceuticals and other organic compounds.
Uses
Used in Pharmaceutical Industry:
7-BROMO-2,3-DIHYDROPYRANO[2,3-B]QUINOLINE is used as a reagent for the preparation of competitive antagonists for the metabotropic glutamate receptor mGluR1. This application is significant in the development of drugs targeting neurological disorders and conditions related to glutamate receptor dysfunction.
Check Digit Verification of cas no
The CAS Registry Mumber 612494-86-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,2,4,9 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 612494-86:
(8*6)+(7*1)+(6*2)+(5*4)+(4*9)+(3*4)+(2*8)+(1*6)=157
157 % 10 = 7
So 612494-86-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H10BrNO/c13-10-3-4-11-9(7-10)6-8-2-1-5-15-12(8)14-11/h3-4,6-7H,1-2,5H2
612494-86-7Relevant articles and documents
Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists
Mabire, Dominique,Coupa, Sophie,Adelinet, Christophe,Poncelet, Alain,Simonnet, Yvan,Venet, Marc,Wouters, Ria,Lesage, Anne S. J.,Van Beijsterveldt, Ludy,Bischoff, Fran?ois
, p. 2134 - 2153 (2007/10/03)
We describe the discovery and the structure-activity relationship of a new series of quinoline derivatives acting as selective and highly potent noncompetitive mGlu1 antagonists. We first identified cis-10 as a fairly potent mGlu1 antagonist (IC50/s