61291-21-2

Basic information

• Product Name: 5-Methylthiazole-2-carboxylic acid
• Synonyms: 5-Methyl-1,3-thiazole-2-carboxylic acid;5-Methylthiazole-2-carboxylic acid;Sodium 5-methyl-1,3-thiazole-2-carboxylate;2-Carboxy-5-methyl-1,3-thiazole
• CAS NO: 61291-21-2
• Molecular Formula: C₅H₅NO₂S
• Molecular Weight: 143.16
• Product Categories: Carboxylic Acids;Thiazoles, Isothiazoles &Benzothiazoles;Carboxylic Acids;Thiazoles, Isothiazoles & Benzothiazoles
• Mol File: 61291-21-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 317.135 °C at 760 mmHg
• Flash Point: 145.598 °C
• Appearance: Off-white/Solid
• Density: 1.418 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• PKA: 0.65±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-Methylthiazole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methylthiazole-2-carboxylic acid(61291-21-2)
• EPA Substance Registry System: 5-Methylthiazole-2-carboxylic acid(61291-21-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 61291-21-2(Hazardous Substances Data)

Usage

Uses

5-Methylthiazole-2-carboxylic acid is used as pharmaceutical intermediate.

InChI:InChI=1/C5H5NO2S/c1-3-2-6-4(9-3)5(7)8/h2H,1H3,(H,7,8)

Upstream product

• 58334-08-0 ethyl 5-methylthiazole-2-carboxylate 
• 14527-41-4 thiazole-5-carboxylic acid 

Downstream Products

• 79247-98-6 5-Methyl-thiazole-2-carboxylic acid methyl ester 
• 1034150-78-1 N-[(1R,2S)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide 
• 960235-24-9 ethyl 5-(bromomethyl)thiazole-2-carboxylate 
• 58334-08-0 ethyl 5-methylthiazole-2-carboxylate 

Relevant articles and documents

HIV protease inhibitors

The present invention discloses novel isoquinoline carboxamide derivatives which are HIV protease inhibitors or prodrugs thereof, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds are hydroxyethylamine tripeptide mimetics which act as inhibitors of the HIV aspartyl protease, an essential enzyme in the replicative life cycle of HIV. Consequently, the compounds of this invention may be advantageously used in the treatment of HIV infection, either alone or in combination with other inhibitors of HIV viral replication or with pharmacoenhancers such as cytochrome P450 inhibitors.