61305-33-7

Basic information

• Product Name: 2-Cyclopenten-1-ol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
• Synonyms: (+/-)-(1S,4R)-4-(tert-butyldimethylsilyloxy)cyclopent-2-enol;cis 4-[(1,1-dimethylethyl)dimethylsilyloxy]cyclopent-2-en-1-ol;cis-4-(tert-butyldimethylsilylanyloxy)cyclopent-2-en-1-ol;(+/-)-cis-4-tert-butyldimethylsilyloxy-2-cyclopentenol;cis-4-(tert-butyl-dimethylsilanyloxy)-cyclopent-2-enol;cis-2-cyclopentene-1,4-diol mono-tert-butyldimethylsilyl ether
• CAS NO: 61305-33-7
• Molecular Formula: C11H22O2Si
• Molecular Weight: 214.38
• Mol File: 61305-33-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 245.9±40.0 °C(Predicted)
• Density: 0.94±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-Cyclopenten-1-ol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopenten-1-ol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(61305-33-7)
• EPA Substance Registry System: 2-Cyclopenten-1-ol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(61305-33-7)

Safety Data

• Hazardous Substances Data: 61305-33-7(Hazardous Substances Data)

Upstream product

• 1589-82-8 phenylmagnesium bromide 

Downstream Products

• 60176-77-4 (1S,4R)-4-hydroxy-2-cyclopentenyl acetate 
• 930-59-6 (1S*,3R*)-3-methylcyclopentan-1-ol 
• 61305-24-6 dl-cis-4-hydroxy-2-cyclopentenyl benzoate 
• 63699-54-7 (-)-4(R)-hydroxy-2-cyclopenten-1(S)-yl benzoate 
• 63699-53-6 (+)-4(S)-hydroxy-2-cyclopenten-1(R)-yl benzoate 
• 139914-48-0 3-(benzyloxy)cyclopentan-1-one 
• 150338-78-6 (1S,4R)-cis-1-benzyloxycyclopent-2-en-4-ol 
• 1416429-78-1 C₁₇H₂₄O₂SeSi 

Relevant articles and documents

Synthesis of the active form of loxoprofen by using allylic substitutions in two steps

High regioselectivity for allylic substitution of the cyclopentenyl picolinate 5 with benzylcopper reagent was attained with ZnBr2, and the finding was applied to the p-BrC6H4CH2 reagent. The cyclopentene moiety in the product was reduced to the cyclopentane, and the p-BrC6H4 was converted to the "Cu"C6H4 for the second allylic substitution with picolinate 8 to furnish the title compound after oxidative cleavage of the resulting olefin moiety.