61360-99-4

Basic information

• Product Name: 2-Propenamide, 2-methyl-N-[(4-methylphenyl)sulfonyl]-
• CAS NO: 61360-99-4
• Molecular Formula: C11H13NO3S
• Molecular Weight: 239.295
• Mol File: 61360-99-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, 2-methyl-N-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, 2-methyl-N-[(4-methylphenyl)sulfonyl]-(61360-99-4)
• EPA Substance Registry System: 2-Propenamide, 2-methyl-N-[(4-methylphenyl)sulfonyl]-(61360-99-4)

Safety Data

• Hazardous Substances Data: 61360-99-4(Hazardous Substances Data)

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 920-46-7 Methacryloyl chloride 
• 79-41-4 poly(methacrylic acid) 
• 4083-64-1 Tosyl isocyanate 
• 7677-24-9 trimethylsilyl cyanide 
• 1242029-29-3 N-(prop-2-yn-1-yl)-N-tosylmethacrylamide 

Relevant articles and documents

Stereoselective and Atom-Economic Alkenyl C-H Allylation/Alkenylation in Aqueous Media by Iridium Catalysis

A practical and atom-economic protocol for the stereoselective preparation of various 1,4-and 1,3-diene skeletons through iridium-catalyzed directed olefinic C-H allylation and alkenylation of NH-Ts acrylamides in water was developed. This reaction tolerated a wide scope of substrates under simple reaction conditions and enabled successful gram-scale preparation. Furthermore, an asymmetric variant of this reaction giving enantioenriched 1,4-dienes was achieved employing a chiral diene-iridium complex as the catalyst.

Rhodium-Catalyzed Defluorinative Vinylation of gem-Difluoroalkenes for the Synthesis of 2-Fluoro-1,3-dienes

Herein, we present a strategy for the formation of 2-fluoro-1,3-diene derivatives via rhodium-catalyzed direct C(sp2)—C(sp2) cross-coupling of gem-difluoroalkenes and acrylamides. By merging Rh(III)-catalyzed C(sp2)–H bond activation and nucleophilic addition/F-elimination of gem-difluoroalkene, an efficient defluorinative vinylation reaction is uncovered, which leads to the generation of 2-fluoro-1,3-dienes in moderate to good yields with excellent stereoselectivity under mild conditions. Preliminary mechanistic study suggests unique effects of fluorine substituents which allow the reactivity profile not observed with the congeners bearing heavier halides.

Rhodium(iii)-catalyzed C-H allylation of electron-deficient alkenes with allyl acetates

Rhodium-catalyzed C-H allylation of acrylamides with allyl acetates is reported. The use of weakly coordinating directing group resulted in high reaction efficiency, broad functionality tolerance and excellent γ-selectivity, which opens a new synthetic pathway for the access of 1,4-diene skeletons.