61368-63-6

Basic information

• Product Name: 2',3'-O-(2,4,6-TRINITROPHENYL) ADENOSINE 5'-TRIPHOSPHATE MONOLITHIUM TRISODIUM SALT
• Synonyms: 2',3'-O-(2,4,6-TRINITROPHENYL) ADENOSINE 5'-TRIPHOSPHATE MONOLITHIUM TRISODIUM SALT;TNP-ATP MONOLITHIUM TRISODIUM SALT;2’,3’-o-(2,4,6-trinitro-cyclohexadienylidine)adenosine5’-triphosphate;2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate;TNP-ATP;TNP-ATP hydrate;2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate trilithium disodium salt;2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphatetetra(triethylammonium)salt
• CAS NO: 61368-63-6
• Molecular Formula: C22H14LiN11Na3O25P3
• Molecular Weight: 1001.24
• Product Categories: Purinergics P2 receptor
• Mol File: 61368-63-6.mol
• Article Data: 0

Chemical Properties

• Appearance: red to orange/solid
• Storage Temp.: −20°C
• Solubility: H2O: >20 mg/mL
• CAS DataBase Reference: 2',3'-O-(2,4,6-TRINITROPHENYL) ADENOSINE 5'-TRIPHOSPHATE MONOLITHIUM TRISODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3'-O-(2,4,6-TRINITROPHENYL) ADENOSINE 5'-TRIPHOSPHATE MONOLITHIUM TRISODIUM SALT(61368-63-6)
• EPA Substance Registry System: 2',3'-O-(2,4,6-TRINITROPHENYL) ADENOSINE 5'-TRIPHOSPHATE MONOLITHIUM TRISODIUM SALT(61368-63-6)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 61368-63-6(Hazardous Substances Data)

Usage

Description

2',3'-O-(2,4,6-TRINITROPHENYL) ADENOSINE 5'-TRIPHOSPHATE MONOLITHIUM TRISODIUM SALT, also known as TNP-ATP, is an organophosphate oxoanion derived from the deprotonation of the triphosphate hydroxyl groups of adenosine triphosphate (ATP). It is characterized by the presence of a trinitrophenyl group, which is a strong chromophore, making it useful in various applications due to its unique properties.

Uses

Used in Research and Diagnostic Applications:
TNP-ATP is used as a research and diagnostic tool for studying the function and regulation of ATP-binding proteins and enzymes. The trinitrophenyl group allows for easy detection and tracking of the molecule in various assays, making it a valuable tool in the field of molecular biology and biochemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, TNP-ATP is utilized as a starting material for the synthesis of various ATP analogs and derivatives with potential therapeutic applications. These analogs can be used to modulate the activity of ATP-binding proteins, which are often targeted in the development of new drugs for various diseases.
Used in Analytical Chemistry:
TNP-ATP is employed as a reference compound in analytical chemistry for the development and validation of methods for the detection and quantification of ATP and its analogs. Its unique chromophore allows for accurate and sensitive measurements, making it an essential component in the development of new analytical techniques.
Used in Biotechnology:
In the biotechnology industry, TNP-ATP can be used as a component in the design of biosensors and other diagnostic devices that rely on the detection of ATP or its analogs. The trinitrophenyl group provides a distinct signal that can be easily detected, making it a valuable asset in the development of innovative biotechnological applications.

Biological Activity

High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X 1 , P2X 3 and heteromeric P2X 2/3 receptors with IC 50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X 2 , P2X 4 and P2X 7 .