61371-55-9 Usage
Description
Griffonilide is a bioactive compound derived from the Semiaquilegia adoxoides root, which is a traditional anticancer herb. It possesses potent anticancer properties and has been extensively studied for its potential therapeutic applications in cancer treatment.
Uses
Used in Anticancer Applications:
Griffonilide is used as an anticancer agent for its ability to inhibit the growth and proliferation of cancer cells. It has been found to be effective against various types of cancer, including solid tumors, by targeting and disrupting essential cellular processes within the cancer cells.
Used in Traditional Medicine:
Griffonilide is also used in traditional medicine as a component of herbal remedies and formulations, where it contributes to the overall therapeutic effects of the treatment, particularly in cancer management and prevention.
Used in Pharmaceutical Research:
In the field of pharmaceutical research, Griffonilide serves as a valuable compound for the development of novel anticancer drugs. Its unique properties and mechanisms of action make it a promising candidate for further investigation and potential integration into new cancer treatment strategies.
Used in Drug Delivery Systems:
Similar to gallotannin, Griffonilide can also be incorporated into drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. Researchers are exploring various organic and metallic nanoparticles as carriers for Griffonilide, aiming to improve its effectiveness in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 61371-55-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,3,7 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 61371-55:
(7*6)+(6*1)+(5*3)+(4*7)+(3*1)+(2*5)+(1*5)=109
109 % 10 = 9
So 61371-55-9 is a valid CAS Registry Number.
61371-55-9Relevant articles and documents
Tylosema esculentum extractives and their bioactivity
Mazimba, Ofentse,Majinda, Runner R.T.,Modibedi, Ceciliah,Masesane, Ishmael B.,Cenci?, Avrelija,Chingwaru, Walter
, p. 5225 - 5230 (2011)
The investigation of Tylosema esculentum (Morama) husks, cotyledons, and tuber yielded griffonilide 2, compound 1, griffonin 3, gallic acid 4, protocatechuic acid 5, β-sitosterol 6, behenic acid 7, oleic acid 8, sucrose 9, 2-O-ethyl-α-d-glucopyranoside 10, kaempferol 11 and kaempferol-3-O-β-d-glucopyranoside 12. The structures of the isolates were determined by NMR, HR-TOF EIMS, IR and UV-vis spectroscopy, and by comparison with literature data. The husk EtOAc and n-butanol extracts demonstrated >90% DPPH radical scavenging activity at concentrations of 25, 50 and 250 μg/mL. Furthermore the husk extracts showed higher total phenolic content (233 mg GAE/g). The extractives exhibited minimum inhibitory quantities of 50-100 μg or no activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Candida albicans. The tuber extracts were inactive against Caco-2 and Hela cell lines, while the husk extracts showed low activity against Caco-2 and Vero cell line with IC50 values >400 μg/mL. The GC-MS analysis showed the beans and tuber non-polar (n-hexane) extracts major constituents as fatty acids.
