614-22-2Relevant articles and documents
N,O-Benzyl Protection of Structurally Varied Amines and Phenols Using Wells-Dawson Heteropolyacid Catalyst
Boughaba, Sara,Aouf, Zineb,Zerrouki, Rachida,Aouf, Nour Eddine
, p. 301 - 310 (2021/05/24)
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Gentle method for carbonylation and arylation reaction of urea compounds
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Paragraph 0015-0019; 0020; 0021; 0022; 0023; 0024, (2018/01/12)
The invention discloses a gentle method for carbonylation and arylation reaction of urea compounds. The method includes a step of performing a coupling carbonylation reaction to a halogenated aromatic compound with a urea compound under a gentle condition to produce a ureide compound, palladium acetate being a catalyst, triethylamine being an alkali, and pentacarbonyl iron being a CO release source. The method has simple operations and gentle reaction condition, is low in usage amount of the catalyst and the CO release source, is low in toxicity and cost, has wide substrate applicability and high yield of the target product, and can be widely applied to preparation of a ureide compound medicine molecule.
Solid-phase synthesis of disubstituted N -acylureas from resin-bound ureas and acyl chlorides
Haecker, Hans-Georg,Meusel, Manuela,Aschfalk, Melanie,Guetschow, Michael
experimental part, p. 59 - 64 (2011/04/15)
Acylureas (ureides) are valued for their important biological activities. Whereas cyclic acylureas have frequently been the object of solid-phase chemistry, only few reports have focused on the solid-supported preparation of acyclic representatives. We have prepared different types of acylureas on Rink amide resin in three or four steps. The products are either N-acylated (9, 18), N-acylated-N′-alkylated (10, 19), or N-acylated-N-alkylated (22). Characteristic NMR parameters of isomeric acylureas 10, 19, and 22 are discussed.