61403-68-7

Basic information

• Product Name: Benzenepropanoic acid, a-methoxy-, (S)-
• CAS NO: 61403-68-7
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 61403-68-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-methoxy-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-methoxy-, (S)-(61403-68-7)
• EPA Substance Registry System: Benzenepropanoic acid, a-methoxy-, (S)-(61403-68-7)

Safety Data

• Hazardous Substances Data: 61403-68-7(Hazardous Substances Data)

Upstream product

• 90843-50-8 α-methoxy cinnamic acid 
• 63-91-2 L-phenylalanine 
• 90843-50-8 (2Z)-2-methoxy-3-phenylacrylic acid 
• 20312-36-1 L-3-phenyllactic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 1023285-69-9 C₂₉H₃₂F₂N₂O₃ 
• 1643770-72-2 (2S)-1-((3R)-3-benzylmorpholino)-2-methoxy-3-phenylpropan-1-one 
• 1643771-00-9 (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-methoxy-3-phenylpropanoate 
• 1643770-66-4 (S)-1-((S)-3-benzylmorpholino)-2-methoxy-3-phenylpropan-1-one 
• 1333435-25-8 (2S)-methoxy-3-phenylthiopropionic acid S-benzyl ester 
• 1228686-22-3 2((S)-methoxy)-3-phenylpropionic acid 4-chlorophenyl ester 

Relevant articles and documents

OXA-SPIRODIPHOSPHINE LIGAND AND METHOD FOR ASYMMETRIC HYDROGENATION OF alpha, beta-UNSATURATED CARBOXYLIC ACIDS

The present invention provides an oxa-spirodiphosphine ligand having a structure of general Formula (I) below: wherein in general Formula (I), R1, R2, R3 and R4 are the same, and are alkyl, alkoxy, aryl, aryloxy

Oxa-spiral diphosphine ligand and application thereof in alpha, beta-unsaturated carboxylic acid asymmetric hydrogenation

The invention provides an oxa-spiral diphosphine ligand. The oxa-spiral diphosphine ligand has a structure shown by a general formula (I) as shown in description, wherein R1, R2, R3 and R4 in the general formula (I) are same and are alkyl, alkoxy, aryl, aroxyl, or hydrogen atoms; R1, R2, R3 and R4 comprise forms of ring formation, non-ring formation, any two ring formation or multiple-ring formation between pairs; R5 and R6 are alkyl, aryl or hydrogen atoms; and R7 and R8 are alkyl or benzyl or aryl. The invention further provides application of the oxa-spiral diphosphine ligand O-SDP in the alpha, beta-unsaturated carboxylic acid asymmetric hydrogenation. A complex of the oxa-spiral diphosphine ligand O-SDP and ruthenium has excellent activity and enantioselectivity in the asymmetric hydrogenation of the alpha, beta-unsaturated carboxylic acid in multiple types, and a chiral carboxylic acid product is obtained with the enantioselectivity being up to 99%. The synthesis method can be applied to the construction of a core skeleton of chemical molecules with important activity, wherein the chemical molecules comprise Paroxetine, Femoxetine, nipecotic acid and Sacubitril.

Highly enantioselective hydrogenation of α-oxy functionalized α,β-unsaturated acids catalyzed by a ChenPhos-Rh complex in CF3CH2OH

Rhodium complexes coordinated by Chenphos are very effective catalysts for the enantioselective hydrogenation of α-aryloxy- and α-alkoxy-substituted α,β-unsaturated carboxylic acids under mild conditions in CF3CH2OH. The catalytic system could be successfully employed in building the core structure of a new FDA approved drug LCZ 696.