61441-09-6Relevant articles and documents
Total Synthesis of Zephycarinatines via Photocatalytic Reductive Radical ipso-Cyclization
Ichimura, Atsuhiko,Inuki, Shinsuke,Kawabe, Takaaki,Nakagawa, Kohei,Ohno, Hiroaki,Oishi, Shinya,Takeuchi, Haruka
supporting information, p. 21210 - 21215 (2020/09/16)
We report herein a nonbiomimetic strategy for the total synthesis of the plicamine-type alkaloids zephycarinatines C and D. The key feature of the synthesis is a stereoselective reductive radical ipso-cyclization using visible-light-mediated photoredox ca
Pd-Catalyzed/Iodide-Promoted α-Arylation of Ketones for the Regioselective Synthesis of Isocoumarins
Casnati, Alessandra,Maggi, Raimondo,Maestri, Giovanni,Della Ca, Nicola,Motti, Elena
, p. 8296 - 8303 (2017/08/14)
A variety of isocoumarins have been synthesized directly from 2-halobenzoates and ketones through a palladium-catalyzed α-arylation step followed by an intramolecular cyclization process. The addition of iodide anions to the reaction mixture increased yields and selectivities especially when 2-bromobenzoates were employed. This phosphine-free one-pot synthesis features a high functional group tolerance and gives access to richly decorated isocoumarins. This general methodology was successful in the total synthesis of Xyridin A, an important natural product with antibacterial and antifungal activity.
Novel derivatives of indole and pyrrole, method for the production thereof and pharmaceutical compositions containing same
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Paragraph 1660; 1661; 1662; 1663, (2016/10/09)
The invention relates to compounds of formula (I), wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. The invention also relates to drugs containing same.