61468-43-7

Basic information

• Product Name: 1,2,3,4-Tetrahydro-5-quinolinol
• Synonyms: 1,2,3,4-Tetrahydro-5-quinolinol;1,2,3,4-Tetrahydroquinolin-5-ol;5-Quinolinol, 1,2,3,4-tetrahydro-
• CAS NO: 61468-43-7
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.18974
• Mol File: 61468-43-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-5-quinolinol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-5-quinolinol(61468-43-7)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-5-quinolinol(61468-43-7)

Safety Data

• Hazardous Substances Data: 61468-43-7(Hazardous Substances Data)

Usage

General Description

1,2,3,4-Tetrahydro-5-quinolinol, also known as THQ, is a chemical compound with a molecular formula C9H11NO. It is a hydroxy derivative of tetrahydroquinoline and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. THQ possesses antioxidant properties and has been studied for its potential applications in the treatment of neurodegenerative diseases and cancer. It has also been investigated for its role as a metal chelator, which may have implications for the treatment of metal toxicity. Additionally, THQ has been explored in the field of polymer chemistry for its potential as a monomer or crosslinking agent in the production of functional materials.

Upstream product

• 578-67-6 quinolin-5-ol 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 7664-93-9 sulfuric acid 
• 30389-37-8 5-methoxy-1,2,3,4-tetrahydroquinoline 
• 6931-19-7 5-methoxyquinoline 

Downstream Products

• 497068-73-2 tert-butyl 5-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate 
• 944413-77-8 C₁₉H₁₅NO₃ 

Relevant articles and documents

Method for selective catalytic hydrogenation of aromatic heterocyclic compounds in non-hydrogen participation manner

The invention discloses a method for selective catalytic hydrogenation of aromatic heterocyclic compounds in a non-hydrogen participation manner. The method comprises the following steps: by taking 1, 5-cyclooctadiene iridium chloride dimer as a catalyst and phenylsilane as a hydrogen source, carrying out stirring reaction under mild conditions without adding a ligand, namely catalytically hydrogenating the aromatic heterocyclic compounds to obtain hydrogenated products of the aromatic heterocyclic compounds. The method has the advantages of low cost, mild reaction conditions, high selectivity and the like, and special equipment such as a high-pressure kettle and the like and high-temperature conditions which are required when hydrogen is used are avoided.

Palladium supported on magnesium hydroxyl fluoride: An effective acid catalyst for the hydrogenation of imines and N-heterocycles

Palladium catalysts supported on acidic fluorinated magnesium hydroxide Pd/MgF2-x(OH)x were prepared through precipitation or impregnation methods. Applications to the hydrogenation of various aldimines and ketimines resulted in good catalytic activities at mild temperatures using one atmosphere of hydrogen. Quinolines, pyridines and other N-heterocycles were successfully hydrogenated at higher temperature and hydrogen pressure using low palladium loadings and without the use of any acid additive. Such reactivity trend confirmed the positive effect of the Br?nsted and Lewis acid sites from the fluorinated magnesium hydroxide support resulting in the effective pre-activation of N-heterocycle substrates and therefore in the good catalytic activity of the palladium nanoparticles during the hydrogenations. As demonstrated in the hydrogenation of imines, the catalyst was recycled up to 10 times without either loss of activity or palladium leaching. This journal is

Thieno[3,2-d]pyrimidine compound and preparation method and medical application thereof

The invention relates to a thieno[3,2-d]pyrimidine compound and a preparation method and medical application thereof, especially to a compound as shown in the general formula I, a preparation method thereof, a pharmaceutical composition containing the com