614750-82-2

Basic information

• Product Name: Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-
• Synonyms: Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-;1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridine-6-yl-ethanone;Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl- 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridine-6-yl-ethanone;1-(6-methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-ylethanone;2-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1-(6-methylpyridin-2-yl)ethanone
• CAS NO: 614750-82-2
• Molecular Formula: C₁₄H₁₂N₄O
• Molecular Weight: 252.27128
• Mol File: 614750-82-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.62±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-(614750-82-2)
• EPA Substance Registry System: Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-(614750-82-2)

Safety Data

• Hazardous Substances Data: 614750-82-2(Hazardous Substances Data)

Usage

General Description

"Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-" is a chemical compound with a complex structure consisting of a ketone functional group, a methyl-pyridinyl group, and a triazolopyridinyl group. It is used in various research and industrial applications, including in the development of pharmaceuticals and agrochemicals. The compound's unique structure and properties make it a potential candidate for further study and development in the field of chemical synthesis and drug discovery.

InChI:InChI=1S/C14H12N4O/c1-10-3-2-4-12(17-10)13(19)7-11-5-6-14-15-9-16-18(14)8-11/h2-6,8-9H,7H2,1H3

Upstream product

• 614750-85-5 diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate 
• 614750-81-1 [1,2,4]-triazolo[1,5-a]pyridine-6-carbaldehyde 
• 1122-72-1 6-methyl-2-pyridinecarboxaldehyde 

Downstream Products

• 1338072-76-6 C₂₂H₁₆FN₇S 
• 1338072-78-8 C₂₂H₁₆ClN₇S 
• 1338072-80-2 C₂₃H₁₉N₇S 
• 1338072-81-3 C₂₃H₁₆F₃N₇S 
• 1338072-83-5 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(4-methoxyphenyl)-3-(6-methylpyridin-2-yl)-1H-pyrazole-1-carbothioamide 
• 1338072-87-9 C₂₃H₁₆N₈S 
• 1338072-89-1 C₂₃H₁₈N₈OS 
• 1338072-93-7 C₂₂H₁₆ClN₇S 
• 1338072-95-9 C₂₃H₁₉N₇S 
• 1338072-97-1 C₂₃H₁₉N₇OS 
• 1338072-99-3 C₂₃H₁₆F₃N₇OS 
• 1338073-00-9 C₂₂H₁₅F₂N₇S 
• 1338073-02-1 C₂₂H₁₅F₂N₇S 
• 1338073-03-2 C₂₂H₁₅Cl₂N₇S 

Relevant articles and documents

Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin- 2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors

A series of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4] triazolo[1,5-a]pyridin-6-yl)thiazoles 12a-ab, 13a, 13b, and 18a-d has been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The N-(3-fluorobenzyl)-4-(6- methylpyridin-2-yl)-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)thiazol-2-amine (12b) inhibited ALK5 phosphorylation with an IC50 value of 7.01 nM and showed 61% inhibition at 30 nM in a luciferase reporter assay using HaCaT cells permanently transfected with p3TP-luc reporter construct.

Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2- yl)-4-([1,2,4triazolo[1,5-apyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

A series of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4triazolo[1,5- apyridin-6-yl)pyrazoles 14a-ae, 16a, 16b, and 21a-c has been prepared and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter ass