614754-32-4 Usage
Description
(R)-1-benzyl-3-hydroxypiperidin-2-one is a chiral chemical compound belonging to the class of piperidinones. The (R) configuration signifies that the substituents are arranged in a clockwise fashion around the chiral center, making it a unique and valuable molecule in the field of chemistry and pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
(R)-1-benzyl-3-hydroxypiperidin-2-one is used as a building block for the synthesis of various pharmaceuticals and bioactive molecules. Its versatile structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Neurodegenerative Disease Treatment:
(R)-1-benzyl-3-hydroxypiperidin-2-one is used as an acetylcholinesterase inhibitor for the potential treatment of neurodegenerative diseases such as Alzheimer's. Its ability to inhibit the enzyme acetylcholinesterase can help improve cognitive function and slow down the progression of the disease.
Used in Chiral Ligand and Organocatalyst Synthesis:
(R)-1-benzyl-3-hydroxypiperidin-2-one is used as a precursor in the synthesis of chiral ligands and organocatalysts. Its chiral nature makes it a valuable starting material for creating enantioselective catalysts, which are essential in the production of enantiomerically pure compounds in various chemical and pharmaceutical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 614754-32-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,4,7,5 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 614754-32:
(8*6)+(7*1)+(6*4)+(5*7)+(4*5)+(3*4)+(2*3)+(1*2)=154
154 % 10 = 4
So 614754-32-4 is a valid CAS Registry Number.
614754-32-4Relevant articles and documents
Transition Metal-Free Selective Double sp3 C-H Oxidation of Cyclic Amines to 3-Alkoxyamine Lactams
Osorio-Nieto, Urbano,Chamorro-Arenas, Delfino,Quintero, Leticia,H?pfl, Herbert,Sartillo-Piscil, Fernando
, p. 8625 - 8632 (2016)
The first chemical method for selective dual sp3 C-H functionalization at the alpha-and beta positions of cyclic amines to their corresponding 3-alkoxyamine lactams is reported. Unlike traditional Cα-H oxidation of amines to amides mediated by transition metals, the present protocol, which involves the use of NaClO2/TEMPO/NaClO in either aqueous or organic solvent, not only allows the Cα-H oxidation but also the subsequent functionalization of the unreactive β-methylene group in an unprecedented tandem fashion and using environmentally friendly reactants.
Chemoenzymatic enantioselective synthesis of 3-hydroxy-2-pyrrolidinones and 3-hydroxy-2-piperidinones
Kamal, Ahmed,Ramana, K. Venkata,Ramana, A. Venkata,Babu, A. Hari
, p. 2587 - 2594 (2007/10/03)
The enantioselective synthesis of 3-hydroxypyrrolidin-2-ones and 3-hydroxy piperidin-2-ones has been carried out in high enantiomeric excess employing immobilized lipase from Pseudomonas cepacia.
