61477-94-9

Basic information

• Product Name: 4-[(2R,6S)-2,6-dimethyl-1-piperidyl]-1-phenyl-1-pyridin-2-yl-butan-1-o l hydrochloride
• Synonyms: 4-[(2R,6S)-2,6-dimethyl-1-piperidyl]-1-phenyl-1-pyridin-2-yl-butan-1-o l hydrochloride;2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, monohydrochloride, cis-;2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, monohydrochloride, cis-(+-)-;2-Pyridinemethanol, a-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-a-phenyl-, monohydrochloride, rel- (9CI);CI 845;Cl 845;Pirmavar;pirmenol hydrochloride
• CAS NO: 61477-94-9
• Molecular Formula: C22H31ClN2O
• Molecular Weight: 375.00
• Mol File: 61477-94-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 171-172 °C
• Boiling Point: 499.6°Cat760mmHg
• Flash Point: 256°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 8.39E-11mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-[(2R,6S)-2,6-dimethyl-1-piperidyl]-1-phenyl-1-pyridin-2-yl-butan-1-o l hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2R,6S)-2,6-dimethyl-1-piperidyl]-1-phenyl-1-pyridin-2-yl-butan-1-o l hydrochloride(61477-94-9)
• EPA Substance Registry System: 4-[(2R,6S)-2,6-dimethyl-1-piperidyl]-1-phenyl-1-pyridin-2-yl-butan-1-o l hydrochloride(61477-94-9)

Safety Data

• Hazardous Substances Data: 61477-94-9(Hazardous Substances Data)

Usage

Description

4-[(2R,6S)-2,6-dimethyl-1-piperidyl]-1-phenyl-1-pyridin-2-yl-butan-1-ol hydrochloride, also known as Pirmenol hydrochloride, is a long-lasting Class Ia antiarrhythmic agent that was introduced in Japan in 1994. It is characterized by its ability to treat atrial and ventricular arrhythmias of diverse etiology and has demonstrated effectiveness in both shortand mid-term treatments of chronic premature ventricular beats, with or without underlying heart disease.

Uses

Used in Cardiology:
4-[(2R,6S)-2,6-dimethyl-1-piperidyl]-1-phenyl-1-pyridin-2-yl-butan-1-ol hydrochloride is used as a cardiac depressant (anti-arrhythmic) for the treatment of atrial and ventricular arrhythmias of diverse etiology. Its effectiveness in clinical trials for the shortand mid-term treatment of chronic premature ventricular beats, with or without underlying heart disease, makes it a valuable asset in cardiology.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-[(2R,6S)-2,6-dimethyl-1-piperidyl]-1-phenyl-1-pyridin-2-yl-butan-1-ol hydrochloride is used as an active pharmaceutical ingredient for the development of antiarrhythmic medications. Its high effectiveness by both intravenous and oral routes allows for immediate suppression, prevention, or termination of cardiac arrhythmias and facilitates the transition to oral prophylactic therapy.
Brand Names:
Pirmavar (Parke-Davis); Plmenol.

Originator

Warner-Lamber (U.S.A.)

InChI:InChI=1/C22H30N2O.ClH/c1-18-10-8-11-19(2)24(18)17-9-15-22(25,20-12-4-3-5-13-20)21-14-6-7-16-23-21;/h3-7,12-14,16,18-19,25H,8-11,15,17H2,1-2H3;1H/t18-,19+,22?;