6149-45-7

Basic information

• Product Name: 3-Hydroxy-3-methylbutanoic acid methyl ester
• Synonyms: 3-Hydroxy-3-methylbutanoic acid methyl ester
• CAS NO: 6149-45-7
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.16
• Mol File: 6149-45-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 70-71 °C(Press: 10 Torr)
• Appearance: /
• Density: 1.027±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.02±0.29(Predicted)
• CAS DataBase Reference: 3-Hydroxy-3-methylbutanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-3-methylbutanoic acid methyl ester(6149-45-7)
• EPA Substance Registry System: 3-Hydroxy-3-methylbutanoic acid methyl ester(6149-45-7)

Safety Data

• Hazardous Substances Data: 6149-45-7(Hazardous Substances Data)

Usage

General Description

3-Hydroxy-3-methylbutanoic acid methyl ester, also known as HMB, is a chemical compound often used as a nutritional supplement and is known to have potential anti-catabolic and anabolic effects. HMB is a metabolite of the amino acid leucine and has been shown to promote muscle protein synthesis and reduce muscle protein breakdown, making it popular among athletes and bodybuilders for muscle building and recovery. In addition to its effects on muscle, HMB has also been studied for its potential impact on various health conditions, including muscle wasting, osteoporosis, and cancer cachexia. Overall, HMB shows promise as a nutritional supplement for enhancing muscle mass and strength, and potentially for managing certain health conditions associated with muscle breakdown.

Upstream product

• 6832-16-2 methyl diazoacetate 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 2568-33-4 3-methyl-butane-1,3-diol 
• 79-20-9 acetic acid methyl ester 
• 67-64-1 acetone 

Relevant articles and documents

Carbenes in a Rigid Matrix. Substituent Effects on the Temperature Dependence of α-Carbonylcarbene Reactions

The temperature dependence of methoxycarbonyl- (1a and b) and benzoyl-carbenes (2a and b) reactions in alcohols has been examined in order to elucidate the scope and limitation of low temperature photolysis as a tool for detecting triplet carbenes.The results reveal that the method cannot be applied to all carbenes but gives important information on the reactivity and/or multiplicity of ground-state carbenes.Low-temperature photolysis of PhCN2CO2Me in an ethanol matrix, for example, resulted in a dramatic increase in C-H insertion products, probably derived from the triplet (1a) via an abstraction-recombination mechanism, at the expense of the singlet product, i.e. the O-H insertion compound, which was shown to be the main product of photolysis at ambient temperature.In marked contrast, (1b) generated in a propan-2-ol matrix at -196 deg C did not result in a major increase in the C-H insertion product.Similar and more contrasting substituent effects on the temperature dependence were observed in the benzoylcarbene system (2).Thus, the Wolff rearrangement of (2a) was almost completely supressed in a rigid matrix at -196 deg C, whereas that of (2b) was not appreciably supressed even at -196 deg C.These differences were explained by considering the effects of the substituent on the ground-state multiplicity of carbene and/or on the relation of the activation energy differences of the singlet and triplet reactions with energy differences between two states.