6151-30-0 Usage
Chemical Properties
bright yellow powder
Uses
Quinacrine Dihydrochloride Dihydrate is a phophoslipase A2 inhibitor.
General Description
Qunacrine is no longer available in theUnited States. It can be considered one of the most toxic ofthe antimalarial drugs even though, at one time, it was commonlyused. It acts at many sites within the cell includingintercalation of DNA strands, succinic dehydrogenase andmitochondrial electron transport, and cholinesterase. It maybe tumorgenic and mutagenic and has been used as a sclerosingagent. Because it is an acridine dye, quinacrine cancause yellow discoloration of the skin and urine.
Check Digit Verification of cas no
The CAS Registry Mumber 6151-30-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,5 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6151-30:
(6*6)+(5*1)+(4*5)+(3*1)+(2*3)+(1*0)=70
70 % 10 = 0
So 6151-30-0 is a valid CAS Registry Number.
InChI:InChI=1/C23H30ClN3O.ClH.2H2O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);1H;2*1H2
6151-30-0Relevant articles and documents
Process for the preparation of 9-deazaguanine derivatives
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, (2008/06/13)
Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compound to provide a protected guanidino compound. The guanidino is converted to the desired 9-deazaguanine derivative by reacting with trifluoracetic acid or with an alkoxide or hydroxide followed by neutralization with an acid.
