615264-52-3 Usage
Description
4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide is a bioactive compound that has been identified as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2). These enzymes catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and are implicated in the development of atherosclerosis. 4-HYDROXYCINNAMIC ACID (L-PHENYLALANINE METHYL ESTER) AMIDE CAY10486, which is an analog of 4-hydroxycinnamic acid (L-phenylalanine methyl ester) amide, has been shown to inhibit both ACAT-1 and ACAT-2 with an IC50 value of approximately 60 μM. Additionally, CAY10486 inhibits copper-mediated oxidation of low-density lipoproteins by about 28% at a concentration of 3 μM.
Uses
Used in Pharmaceutical Industry:
4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide is used as a lead compound for the development of ACAT inhibitors for the treatment of atherosclerosis. Its ability to inhibit both ACAT-1 and ACAT-2 makes it a promising candidate for further research and development.
Used in Cardiovascular Research:
4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide is used as a research tool to study the role of ACAT enzymes in the development of atherosclerosis and other cardiovascular diseases. It can help researchers understand the mechanisms underlying cholesterol ester formation and its impact on cardiovascular health.
Used in Drug Discovery:
4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide is used as a starting point for the design and synthesis of new ACAT inhibitors with improved potency, selectivity, and pharmacokinetic properties. These new compounds may have potential as therapeutic agents for the treatment of atherosclerosis and related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 615264-52-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,5,2,6 and 4 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 615264-52:
(8*6)+(7*1)+(6*5)+(5*2)+(4*6)+(3*4)+(2*5)+(1*2)=143
143 % 10 = 3
So 615264-52-3 is a valid CAS Registry Number.
615264-52-3Relevant articles and documents
Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size
Lee, Sangku,Han, Jong-Min,Kim, Hyunjung,Kim, Eungsoo,Jeong, Tae-Sook,Lee, Woo Song,Cho, Kyung-Hyun
, p. 4677 - 4681 (2004)
A series of cinnamic acid derivatives were prepared and their biological activities were evaluated in lipoprotein metabolism. Among the tested compounds, 4-hydroxycinnamic acid (l-phenylalanine methyl ester) amide (1) and 3,4-dihydroxyhydrocinammic acid (l-aspartic acid dibenzyl ester) amide (2) showed potent anti-atherogenic and anti-oxidant activities. A series of cinnamic acid derivatives were synthesized and their biological abilities on lipoprotein metabolism were examined. Among the tested compounds, 4-hydroxycinnamic acid (l-phenylalanine methyl ester) amide (1) and 3,4-dihydroxyhydrocinammic acid (l-aspartic acid dibenzyl ester) amide (2) inhibited human acyl-CoA:cholesterol acyltransferase-1 and -2 activities with apparent IC50 around 60 and 95 μM, respectively. Compounds 1 and 2 also served as an antioxidant against copper mediated low-density lipoproteins (LDL) oxidation with apparent IC 50 = 52 and 3 μM, compound 1 and 2, respectively. Additionally, decrease of HDL-particle size under presence of LDL was inhibited by the 1 at 307 μM of final concentration. Treatment of the 1 or 2 did not influence normal growth of RAW264.7 without detectable cytotoxic activity from a cell viability test. These results suggest that the new cinnamic acid derivatives possess useful biological activity as an anti-atherosclerotic agent with inhibition of cellular cholesterol storage and transport by the both ACAT, inhibition of LDL-oxidation, HDL particle size rearrangement.
