61530-30-1

Basic information

• Product Name: (1R)-1-METHYLPROPYL-4-METHYLBENZENESULFONATE
• Synonyms: RARECHEM AK HZ 0029;(R)-2-(4-METHYLPHENYL)SULFONYLOXY-BUTANE;(R)-(-)-1-METHYLPROPYL 4-METHYLBENZENESULFONATE;(1R)-1-METHYLPROPYL-4-METHYLBENZENESULFONATE;(R)-(-)-1-METHYLPROPYL 4-METHYLBENZENE-&;(R)-Butanol-2-(1-p-toluenesulfonate);(R)-(-)- Methylpropyl 4- Methylbenzenesulfonate
• CAS NO: 61530-30-1
• Molecular Formula: C₁₁H₁₆O₃S
• Molecular Weight: 228.31
• Mol File: 61530-30-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 139-141 °C(lit.)
• Flash Point: 110 °C
• Appearance: /
• Density: 1.12 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000348mmHg at 25°C
• Refractive Index: n20/D 1.504(lit.)
• CAS DataBase Reference: (1R)-1-METHYLPROPYL-4-METHYLBENZENESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-1-METHYLPROPYL-4-METHYLBENZENESULFONATE(61530-30-1)
• EPA Substance Registry System: (1R)-1-METHYLPROPYL-4-METHYLBENZENESULFONATE(61530-30-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39
• RIDADR: UN 1760 8/PG 3
• Hazardous Substances Data: 61530-30-1(Hazardous Substances Data)

Usage

General Description

(1R)-1-Methylpropyl-4-methylbenzenesulfonate is a chemical compound that belongs to the class of sulfonates. It is also known by the trade name Mesna and is often used as a protective agent to prevent damage to the bladder caused by certain chemotherapy drugs. Mesna works by binding to the toxic metabolites of these drugs and preventing them from causing harm to the bladder tissue. It is commonly administered intravenously and has shown to be effective in reducing the incidence of hemorrhagic cystitis in patients undergoing chemotherapy. Additionally, Mesna has also been investigated for its potential use in other medical applications such as treatment of interstitial cystitis and radiation-induced cystitis.

InChI:InChI=1/C11H16O3S/c1-4-10(3)14-15(12,13)11-7-5-9(2)6-8-11/h5-8,10H,4H2,1-3H3/t10-/m1/s1

Upstream product

• 4221-99-2 (S)-2-butanol 
• 104-15-4 toluene-4-sulfonic acid 
• 80-48-8 methyl p-toluene sulfonate 
• 14898-79-4 (2R)-butan-2-ol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 4909-81-3 (1S)-methylpropyl benzoate 
• 93779-85-2 (S)-(+)-2-butyl p-tolyl sulfide 
• 106-98-9 1-butylene 
• 624-64-6 trans-2-Butene 
• 1536-78-3 2-butyl trifluoroacetate 
• 214117-54-1 4-(4-Bromo-phenyl)-2-((S)-sec-butyl)-2,4-dihydro-[1,2,4]triazol-3-one 
• 153896-47-0 (S)-2-(sec-butyl)-4-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 87106-27-2 (S)-2-methyl-1-phenylsulfonylbutane 

Relevant articles and documents

Optical Stability of Carbanions Derived from Sulphoximides and Sulphilimines

Pairs of diastereomeric sulphoximides and sulphilimines of known absolute configuration have been converted into the corresponding carbanions, which have a definite optical stability.

Stereocontrolled C(sp3)-P bond formation with non-activated alkyl halides and tosylates

The C(sp3)-P bond is formed via the reaction between P-H compounds and non-activated alkyl electrophiles, especially secondary alkyl halides and tosylates. This reaction proceeds via an SN2 mechanism with inversion of configuration, so it can be used to form C-P bonds with stereocontrol from chiral secondary alcohols.

SMALL MOLECULE INHIBITORS OF FIBROSIS

Described herein are compounds and compositions for the treatment of a fibrotic disease.