6154-04-7

Basic information

• Product Name: 5-Amino-2-methyl-2H-tetrazole
• Synonyms: 5-AMINO-2-METHYL-2H-TETRAZOLE;2-METHYL-5-AMINO-1H-TETRAZOLE;RARECHEM AQ NN 0463;TIMTEC-BB SBB001742;2H-Tetrazol-5-amine, 2-methyl-;2H-tetrazol-5-amine,2-methyl-;2H-Tetrazole, 5-amino-2-methyl-;2H-tetrazole,5-amino-2-methyl-
• CAS NO: 6154-04-7
• Molecular Formula: C₂H₅N₅
• Molecular Weight: 99.09
• EINECS: 1312995-182-4
• Mol File: 6154-04-7.mol
• Article Data: 20

Chemical Properties

• Melting Point: 104.5-105.5 °C
• Boiling Point: 282.9 °C at 760 mmHg
• Flash Point: 124.9 °C
• Appearance: /
• Density: 1.75 g/cm³
• Vapor Pressure: 0.00327mmHg at 25°C
• Refractive Index: 1.794
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.43±0.10(Predicted)
• CAS DataBase Reference: 5-Amino-2-methyl-2H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2-methyl-2H-tetrazole(6154-04-7)
• EPA Substance Registry System: 5-Amino-2-methyl-2H-tetrazole(6154-04-7)

Safety Data

• Hazardous Substances Data: 6154-04-7(Hazardous Substances Data)

Usage

General Description

5-Amino-2-methyl-2H-tetrazole is a chemical compound with the molecular formula C2H6N6. It is a white crystalline solid that is soluble in water and has a melting point of 176-177 degrees Celsius. 5-Amino-2-methyl-2H-tetrazole is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and pigments. It can also be used as a stabilizer for rocket propellants and explosives. 5-Amino-2-methyl-2H-tetrazole is considered to be relatively stable under normal conditions but should be handled with care due to its potential hazardous properties.

InChI:InChI=1/C2H5N5/c1-7-5-2(3)4-6-7/h1H3,(H2,3,5)

Upstream product

• 186581-53-3 diazomethane 
• 4418-61-5 5-aminotetrazole 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 4418-61-5 5-amino-2H-tetrazole 
• 949089-83-2 N,N-dibenzyl-2-methyl-2H-tetrazol-5-amine 
• 949089-95-6 N,N-dibenzyl-1-methyl-1H-tetrazol-5-amine 
• 616-38-6 carbonic acid dimethyl ester 
• 15454-54-3 5-amino-1H-tetrazole monohydrate 

Downstream Products

• 6154-06-9 5-Acetamino-2-methyl-tetrazol 
• 93680-38-7 3-(p-bromophenyl)-1-(2'-methyltetrazol-5'-yl)triazene 
• 956631-60-0 C₁₁H₇F₆N₅ 
• 669080-86-8 [3,5-bis(trifluoromethyl)phenylmethyl](2-methyl-2H-tetrazol-5-yl)amine 
• 911135-51-8 N-({2-[4-(3-chloropropoxy)phenyl]-1,3-oxazol-4-yl}methyl)-2-methyl-2H-tetrazol-5-amine 
• 949089-41-2 [2-(cyclohexyl-methoxy-methyl)-5-trifluoromethyl-benzyl]-(2-methyl-2H-tetrazol-5-yl)-amine 
• 949089-49-0 N-(2-(1-methoxycycloheptyl)-5-(trifluoromethyl)benzyl)-2-methyl-2H-tetrazol-5-amine 
• 939039-52-8 C₁₅H₉ClF₄N₆ 
• 74-90-8 hydrogen cyanide 
• 420-04-2 CYANAMID 
• 2053-29-4 methyleneamine 

Relevant articles and documents

Synthesis and antileishmanial activity of 1,2,4,5-tetraoxanes against leishmania donovani

A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 μm. The most active tetraoxane, compound LC140, exhibited an IC50 value of 2.52 ± 0.65 μm on L. donovani intramacrophage amastigotes, with a selectivity index of 13.5. This compound reduced the liver parasite burden of L. donovani-infected mice by 37% after an intraperitoneal treatment at 10 mg/kg/day for five consecutive days, whereas miltefosine, an antileishmanial drug in use, reduced it by 66%. These results provide a relevant basis for the development of further tetraoxanes as effective, safe, and cheap drugs against leishmaniasis.

NEW ENDOPEROXIDE COMPOUNDS, PROCESS FOR OBTAINING THEM AND USES THEREOF FOR CONTROL OF PERKINSIOSIS IN BIVALVES

The present invention relates to new endoperoxide compounds and compositions, and to a process for producing them for prophylaxis and control of perkinsiosis in bivalves. Endoperoxide compounds with biological activity against Perkinsus olseni include 13

2-Methyl-substituted monotetrazoles in copper(ii) perchlorate complexes: manipulating coordination chemistry and derived energetic properties

A proposed correlation between coordination chemistry and deduced energetic properties (thermal behaviour, and sensitivities towards mechanical and optical stimuli) of copper(ii) complexes is investigated. Starting from a system comprising Cu(ClO4)2 and either of the ligands 2-methyl-5-aminotetrazole (1, 2-MAT) or 2-methyl-5H-tetrazole (2, 2-MTZ), typically altered parameters like the metal(ii) centre, ligand, or counterion were predefined. Instead, solely slight changes in ligand concentration and the solvent system were implemented in order to provide an insight into structure-property relationships of energetic coordination compounds (ECC) of this type. As a result, five highly energetic complexes [Cu(H2O)2(2-MAT)4](ClO4)2·H2O (3), [Cu(H2O)2(2-MAT)4](ClO4)2 (4), [Cu(H2O)2(2-MAT)4](ClO4)2·2 2-MAT (5), [Cu(ClO4)2(H2O)2(2-MAT)2] (6), and [Cu(H2O)2(2-MTZ)4](ClO4)2 (7) were synthesized and, except for 5, elaborately characterized. Besides structural elucidation via X-ray diffraction, NIR-spectroscopy, differential thermal analysis (DTA), standard sensitivity measurements (impact, friction, and electrostatic discharge), UV/vis-spectroscopy, and optical initiation experiments were conducted to deduce a precise relationship between coordination chemistry and the consequential energetic characteristics of these complexes.