6155-37-9Relevant articles and documents
Upregulation of p53 through induction of MDM2 degradation: Amino acid prodrugs of anthraquinone analogs
Anifowose, Abiodun,Yuan, Zhengnan,Yang, Xiaoxiao,Pan, Zhixiang,Zheng, Yueqin,Zhang, Zhongwei,Wang, Binghe
, (2020)
Previously, we reported a class of MDM2-MDM4 dimerization inhibitors that upregulate p53 and showed potent anticancer activity in animal models. However, water solubility hinders their further development. Herein we describe our effort to develop a prodru
Preparation method of parietic acid-amino acid conjugate
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Paragraph 0018-0026, (2019/06/08)
The invention belongs to the technical field of organic compound synthesis, and particularly relates to a preparation method of a parietic acid-amino acid conjugate. The preparation method comprises the following steps of weighing 1 to 2g of methyl methacrylate; putting the methyl methacrylate into a reaction container; then adding 35 to 45ml of DMAP, 0.3 to 0.8g of strong base sodium hydride and1 to 3g of halohydrocarbon at the reaction temperature of 100 to 120 DEG C for the reaction time of 10 to 25min; then, adding 40 to 60 ml of hydrochloric acid solution; performing constant temperaturereaction for 5 to 10min; after the reaction is completed, performing extraction by dichloromethane; adding the extracted products into 35 to 38ml of sodium hydroxide solution; performing reaction atthe temperature of 50 to 60 DEG C for 15 to 30min; performing high-speed stirring; then regulating the pH into a weak acid state; adding 1 to 3g of amino-acid ester; performing room temperature stirring reaction for 5 to 10min; adding 40 to 60ml of hydrochloric acid solutions; performing constant temperature reaction for 5 to 10min; after the reaction is completed, performing extraction for 2 to 4times by dichloromethane; after the solid is separated, performing filtering; performing drying by anhydrous sodium sulfate; obtaining a finished product. The preparation method has the advantages that the dissolution is easy; the bioavailability is high; the process equipment requirement conditions are low; the process steps are simple; the synthesis rate is high, and the like.
Novel Oxidative Transformation: Regiospecific Preparation of Naturally Occurring 1-Hydroxyanthraquinones
Hauser, Frank M.,Prasanna, Subbarao
, p. 383 - 384 (2007/10/02)
A brief reaction sequence for synthesis of the naturally occurring anthraquinones 1-hydroxyanthraquinone (4a), 1-hydroxy-2-methylanthraquinone (4b), pachybasin (4c), chrysophanol (5a), and rhein (5c) has been developed.