61560-95-0

Basic information

• Product Name: Benzeneacetic acid, a-oxo-3-(trifluoromethyl)-
• CAS NO: 61560-95-0
• Molecular Formula: C9H5F3O3
• Molecular Weight: 218.132
• Mol File: 61560-95-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, a-oxo-3-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-oxo-3-(trifluoromethyl)-(61560-95-0)
• EPA Substance Registry System: Benzeneacetic acid, a-oxo-3-(trifluoromethyl)-(61560-95-0)

Safety Data

• Hazardous Substances Data: 61560-95-0(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 76783-59-0 ethyl 3-(trifluoromethyl)benzoate 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 110193-60-7 2-(3-Trifluoromethylphenyl)-2-oxoacetic acid ethyl ester 
• 349-76-8 3'-(trifluoromethyl)acetophenone 

Downstream Products

• 87736-04-7 5-Hydroxy-6-(3-trifluoromethyl-phenyl)-pyrazine-2,3-dicarbonitrile 
• 1432053-94-5 ethyl 5-(3-(trifluoromethyl)phenyl)-1,3,4-oxadiazole-2-carboxylate 
• 1638125-55-9 benzo[d]oxazol-2-yl(3-(trifluoromethyl)phenyl)methanone 
• 1613439-83-0 N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxo-2-(3-trifluoromethylphenyl)acetamide 
• 1450993-98-2 (2-(pyridin-2-yloxy)phenyl)(3-(trifluoromethyl)phenyl)methanone 
• 454-92-2 3-(trifluoromethyl)benzoic acid 

Relevant articles and documents

Photoredox Catalysis Enables Decarboxylative Cyclization with Hypervalent Iodine(III) Reagents: Access to 2,5-Disubstituted 1,3,4-Oxadiazoles

A novel approach to 2,5-disubstituted 1,3,4-oxadiazoles derivatives via a decarboxylative cyclization reaction by photoredox catalysis between commercially available α-oxocarboxylic acids and hypervalent iodine(III) reagent is described. This powerful transformation involves the coupling reaction between two different kinds of radical species and the formation of C-N and C-O bonds.

Cationic Ir/Me-BIPAM-catalyzed asymmetric intramolecular direct hydroarylation of α-ketoamides

Asymmetric intramolecular direct hydroarylation of α-ketoamides gives various types of optically active 3-substituted 3-hydroxy-2-oxindoles in high yields with complete regioselectivity and high enantioselectivities (84-98 % ee). This is realized by the use of the cationic iridium complex [Ir(cod) 2](BArF4) and the chiral O-linked bidentate phosphoramidite (R,R)-Me-BIPAM. Carbon's got a brand new bond: Asymmetric intramolecular direct hydroarylation of α-ketoamides gives various optically active 3-substituted 3-hydroxy-2-oxindoles in high yields with complete regioselectivity and high enantioselectivities. This is realized by the use of an asymmetric cationic iridium complex formed in situ (see Scheme).

Palladium-catalyzed decarboxylative coupling of α-oxocarboxylic acids with C(sp2)-H of 2-aryloxypyridines

An efficient palladium-catalyzed decarboxylative ortho-acylation of 2-aryloxypyridines with α-oxocarboxylic acids is described. In this new transformation, the aromatic C(sp2)-H bond was successfully acylated to give diverse aromatic ketones regioselectively in moderate to good yields. The pyridine group can be removed easily after the acylation to give the corresponding 2-hydroxy aromatic ketones. Copyright