61573-79-3 Usage
Description
3-Hydroxy-1-azabicyclo[2.2.2]octane-3-Methanol is an organic compound that plays a significant role in the synthesis of pharmaceuticals, particularly as an impurity in the production of Cevimeline, a muscarinic M1 and M3 receptor agonist. It is also utilized in the preparation of agonists at nicotinic acetylcholine receptors, contributing to its importance in the development of medications targeting specific receptors.
Uses
Used in Pharmaceutical Industry:
3-Hydroxy-1-azabicyclo[2.2.2]octane-3-Methanol is used as an impurity in the synthesis of Cevimeline (C283500) for its role as a novel muscarinic M1 and M3 receptor agonist. This application is crucial in the development of medications that target these receptors, potentially leading to treatments for various conditions.
Additionally, 3-Hydroxy-1-azabicyclo[2.2.2]octane-3-Methanol is used as a component in the preparation of agonists at nicotinic acetylcholine receptors. This application is vital for the creation of drugs that can modulate the activity of these receptors, which are involved in various physiological processes and could be targeted for the treatment of specific disorders.
Used as a Sialagogue:
3-Hydroxy-1-azabicyclo[2.2.2]octane-3-Methanol also serves as a sialagogue, a substance that promotes the secretion of saliva. This use is beneficial in medical applications where increased saliva production is desired, such as in the treatment of dry mouth conditions or as an aid in the digestive process.
Check Digit Verification of cas no
The CAS Registry Mumber 61573-79-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,5,7 and 3 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 61573-79:
(7*6)+(6*1)+(5*5)+(4*7)+(3*3)+(2*7)+(1*9)=133
133 % 10 = 3
So 61573-79-3 is a valid CAS Registry Number.
61573-79-3Relevant articles and documents
(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2-one], a Conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor
Mullen,Napier,Balestra,Decory,Hale,Macor,Mack,Loch III,Wu,Kover,Verhoest,Sampognaro,Phillips,Zhu,Murray,Griffith,Blosser,Gurley,Machulskis,Zongrone,Rosen,Gordon
, p. 4045 - 4050 (2007/10/03)
Neuronal nicotinic acetylcholine receptors are members of the ligand-gated ion channel receptor superfamily and may play important roles in modulating neurotransmission, cognition, sensory gating, and anxiety. Because of its distribution and abundance in the CNS, the α7 nicotinic receptor is a strong candidate to be involved in some of these functions. In this paper we describe the synthesis and in vitro profile of AR-R17779, (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'oxazolidin-2'-one] (4a), a potent full agonist at the rat α7 nicotinic receptor, which is highly selective for the rat α7 nicotinic receptor over the α4β2 subtype. Preliminary SAR of AR-R17779 presented here indicate that there is little scope for modification of this rigid molecule as even minor changes result in significant loss of the α7 nicotinic receptor affinity.