61601-54-5

Basic information

• Product Name: 1-HYDROXYCARBAZOLE
• Synonyms: 1-HYDROXYCARBAZOLE;9H-carbazol-1-ol
• CAS NO: 61601-54-5
• Molecular Formula: C₁₂H₉NO
• Molecular Weight: 183.206
• Mol File: 61601-54-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 164 °C
• Boiling Point: 431.4°Cat760mmHg
• Flash Point: 214.7°C
• Appearance: /
• Density: 1.362g/cm³
• Vapor Pressure: 4.78E-08mmHg at 25°C
• Refractive Index: 1.815
• PKA: 10.10±0.30(Predicted)
• CAS DataBase Reference: 1-HYDROXYCARBAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-HYDROXYCARBAZOLE(61601-54-5)
• EPA Substance Registry System: 1-HYDROXYCARBAZOLE(61601-54-5)

Safety Data

• Hazardous Substances Data: 61601-54-5(Hazardous Substances Data)

Usage

General Description

1-Hydroxycarbazole, also known as 3-hydroxycarbazole, is a chemical compound with the molecular formula C12H9NO. It is a white to light brown crystalline solid that is soluble in organic solvents but insoluble in water. 1-Hydroxycarbazole is commonly used as a building block in the synthesis of organic compounds and pharmaceuticals. It also has potential applications in the field of optoelectronics and as a corrosion inhibitor. The compound is known to exhibit antioxidant and anti-inflammatory properties, making it a potential candidate for medical and industrial applications. Its unique chemical structure and properties make it a valuable component in various fields of research and industry.

InChI:InChI=1/C12H9NO/c14-11-7-3-5-9-8-4-1-2-6-10(8)13-12(9)11/h1-7,13-14H

Upstream product

• 2229-36-9 1-(2-nitrophenyl)-1H-benzo[d][1,2,3]triazole 
• 3456-99-3 1-oxo-2,3,4,9-tetrahydrocarbazole 
• 86-74-8 9H-carbazole 

Downstream Products

• 115663-18-8 1-ethoxy-9H-carbazole 
• 18992-86-4 1-aminocarbazole 
• 756482-78-7 2-cinnamoyl-1-hydroxycarbazole 
• 875535-12-9 2,3-dihydro-2-phenyl-4-oxopyrano[2,3-a]carbazole 
• 1341186-28-4 1-hydroxy-9-(2-iodobenzoyl)-carbazole 
• 1341186-42-2 9H-carbazol-1-yl 2-iodobenzoate 
• 1341186-27-3 1-hydroxy-9-(2-bromobenzoyl)-carbazole 
• 1341186-39-7 9H-carbazol-1-yl 2-bromobenzoate 
• 1343478-09-0 1-(2-bromo-benzyloxy)-9H-carbazole 
• 1384975-97-6 3-phenyl-10H-furo[2,3-a]carbazole 
• 1384975-76-1 2-(9H-carbazol-1-yloxy)-1-phenylethanone 
• 1620750-22-2 2-amino-4-phenyl-4,11-dihydropyrano[2,3-a]carbazole-3-carbonitrile 

Relevant articles and documents

Alteration of the substrate specificity of the angular dioxygenase carbazole 1,9a-dioxygenase

Carbazole 1,9a-dioxygenase (CARDO) consists of terminal oxygenase (CARDO-O) and electron transport components. CARDO can catalyze specific oxygenation for various substrates: angular dioxygenation for carbazole and dibenzo-p-dioxin, lateral dioxygenation for anthracene, and monooxygenation for methylene carbon of fluorene and sulfide sulfur of dibenzothiophene. To elucidate the molecular mechanism determining its unique substrate specificity, 17 CARDO-O site-directed mutants at amino acid residues I262, F275, Q282, and F329, which form the substrate-interacting wall around the iron active site by CARDO-O crystal structure, were generated and characterized. F329 replacement dramatically reduced oxygenation activity. However, several mutants produced different products from the wild-type enzyme to a large extent: I262V and Q282Y (1-hydroxycarbazole), F275W (4-hydroxyfluorene), F275A (unidentified cis-dihydrodiol of fluoranthene), and I262A and I262W (monohydroxydibenzothiophenes). These results suggest the possibility that the respective substrates bind to the active sites of CARDO-O mutants in a different orientation from that of the wild-type enzyme.