61602-21-9

Basic information

• Product Name: 6H-Imidazo[4,5-e]-1,2,4-triazin-6-one, 1,5-dihydro-3-(4-methoxyphenyl)-1,5-dimethyl-
• CAS NO: 61602-21-9
• Molecular Formula: C13H13N5O2
• Molecular Weight: 271.279
• Mol File: 61602-21-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6H-Imidazo[4,5-e]-1,2,4-triazin-6-one, 1,5-dihydro-3-(4-methoxyphenyl)-1,5-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-Imidazo[4,5-e]-1,2,4-triazin-6-one, 1,5-dihydro-3-(4-methoxyphenyl)-1,5-dimethyl-(61602-21-9)
• EPA Substance Registry System: 6H-Imidazo[4,5-e]-1,2,4-triazin-6-one, 1,5-dihydro-3-(4-methoxyphenyl)-1,5-dimethyl-(61602-21-9)

Safety Data

• Hazardous Substances Data: 61602-21-9(Hazardous Substances Data)

Upstream product

• 52348-60-4 3-(4-methoxyphenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione 

Downstream Products

• 1142408-81-8 3-(4-methoxyphenyl)-1-methyl-5,6-dioxo-1,4,5,6-tetrahydro-1,2,4-triazine 
• 598-50-5 N-Methylurea 

Relevant articles and documents

Synthesis of 6-azapurines by transformation of toxoflavins and reumycins (7-azapteridines) and their cytotoxicities

This paper describes a reliable and facile synthesis of 6-azapurines, 1,5-dimethyl-1H-imidazo[4,5-e][1,2,4]triazin-6(5H)-ones and 5-methyl-5H-imidazo[4,5-e][1,2,4]triazin-6(7H)-ones, by treatment of toxoflavins and reumycins with 10% aqueous or ethanolic sodium hydroxide at 5-70°C or reflux, followed by decarboxylation and oxidation by air along with a benzilic acid type rearrangement. Furthermore, heating the produced 6-azapurines in 10% ethanolic sodium hydroxide afforded the corresponding 1-methyl-5,6-dioxo-1,4,5,6-tetrahydro-1,2,4-triazines with 1-methylurea. The antitumour activities of the 6-azapurines against CCRF-HSB-2 (human T-cell acute lymphoblastoid leukemia) and KB (human oral epidermoid carcinoma) cell lines were also investigated in vitro and some of the compounds showed prospective antitumour activities.