61612-02-0

Basic information

• Product Name: 2-Methylthieno[2,3-d]thiazole
• Synonyms: 2-METHYL THIENO[2,3-D]THIAZOLE;2-Methylthienothiazole
• CAS NO: 61612-02-0
• Molecular Formula: C6H5NS2
• Molecular Weight: 155.24
• Product Categories: Heterocycles;Heterocyclic Compound
• Mol File: 61612-02-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 35-36 °C
• Boiling Point: 96-98°C
• Flash Point: 101°C
• Appearance: /
• Density: 1.385
• Vapor Pressure: 0.06mmHg at 25°C
• Refractive Index: 1.71
• PKA: 2.80±0.40(Predicted)
• CAS DataBase Reference: 2-Methylthieno[2,3-d]thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylthieno[2,3-d]thiazole(61612-02-0)
• EPA Substance Registry System: 2-Methylthieno[2,3-d]thiazole(61612-02-0)

Safety Data

• Hazardous Substances Data: 61612-02-0(Hazardous Substances Data)

Usage

General Description

2-Methylthieno[2,3-d]thiazole is a chemical compound with the molecular formula C6H5NS2. It is a heterocyclic aromatic compound that contains a thiazole ring with a methyl group attached to it. 2-Methylthieno[2,3-d]thiazole is commonly used as a flavoring agent in the food industry, often adding a savory, meaty, or roasted aroma to products. It is also used in the fragrance industry in the production of perfumes and other scented products. Additionally, 2-Methylthieno[2,3-d]thiazole has potential applications in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical compounds. Overall, this chemical compound has a range of industrial and commercial uses due to its distinctive aroma and structural properties.

InChI:InChI=1/C6H5NS2/c1-4-7-6-5(9-4)2-3-8-6/h2-3H,1H3

Upstream product

• 112161-85-0 2-acetylamino-3,5-dibromothiophene 
• 85930-34-3 ethanethioate de S-acetylamino-2 thienyle-3 
• 74598-25-7 (E)-methyl (3-methylthio-2-thienyl) O-p-nitrobenzoylketoxime 
• 60007-32-1 nitro-2 thienyl-3 thiocyanate 
• 85930-29-6 ethanethioate de S-nitro-2 thienyle-3 

Relevant articles and documents

SYNTHESIS OF SUBSTITUTED THIENOTHIAZOLES AND INDOLOTHIAZOLES

Alkylene-, halo-, and aryl-substituted 2-methylthienothiazoles were obtained by the action of phosphorus pentasulfide on the corresponding 2-acetylamino-3-bromo- or 2-acetylamino-3-hydroxythiophenes in an organic solvent with heating. 2-Oximes of halo- and methyl-substituted isatins were converted by reduction and acetylation into 2-hydroxy-3-acetylaminoindoles, from which 2-methylindolo-thiazoles were obtained by the action of phosphorous pentasulfide with heating in xylene.

Condensed Isothiazoles. Part 5. Thienoisothiazoles and Thienoisothiazoles

2,3-Disubstituted thiophens containing a sulphur function (SH, SMe, or SCN) and a carbonyl group (CHO or Ac) have been prepared and converted into thienoisothiasoles.Methods used to prepare 1,2-benzisothiazoles are often inapplicable in the thiophen series.For example, an (E)-methyl (2-methylthio-3-thienyl) O-p-nitrobenzoylketoxime (6) in hot diethylene glycol or acetic acid gave the corresponding 3-acetamido-2-methylthiothiophen (15); in concentrated sulphuric acid at - 5 deg C, it gave the Beckmann rearranged product (15) and a thienothiazole (19).Similarly, (E)-methyl (3-methylthio-2-thienyl) O-p-nitrobenzoyl ketoxime (42) gave 2-methylthienothiazole with concentrated sulphuric acid, but with acetic acid it gave the thienoisothiazole (43) and 2-acetamido-3-methylthiothiophen.Heating the (E)-2-mercaptothiophen-3-carbaldoxime (27) in an inert solvent gave the corresponding thienoisothiazole (14); the (E)-3-mercaptothiophen-2-carbaldoxime (47) cyclised in hot AcOH-Ac2O, to give the thienoisothiazole (44).Thienoisothiazoles were also prepared by treating a methyl (2-mercapto-3-thienyl) ketone (21) with chloramine and by heating a 2-iminothieno-3,1,4-oxathiazepine (29) in an inert solvent.The products obtained by selective S-alkylation of 3,5-bis(sodiomercapto)isothiazole-4-carbonitrile with ethyl bromoacetate and iodomethane were cyclised, to give 4-aminothienoisothiazole derivatives (34) and (36).