61671-80-5 Usage
Description
5-FLUORO-2'-O-METHYLURIDINE, also known as 5-FMU, is a modified nucleoside with a fluorine atom at the 5th position and a methyl group at the 2'-O position of the uridine molecule. It is a synthetic compound that has been studied for its potential applications in various fields, particularly in the pharmaceutical and biotechnology industries.
Uses
Used in Pharmaceutical Industry:
5-FLUORO-2'-O-METHYLURIDINE is used as an antineoplastic agent for the treatment of Ehrlich ascites carcinoma cells. It functions by inhibiting cell proliferation, which is a critical process in the growth and spread of cancer cells. 5-FLUORO-2'-O-METHYLURIDINE has shown promise in targeting and reducing the viability of cancer cells, making it a potential candidate for further research and development in cancer therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 61671-80-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,6,7 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 61671-80:
(7*6)+(6*1)+(5*6)+(4*7)+(3*1)+(2*8)+(1*0)=125
125 % 10 = 5
So 61671-80-5 is a valid CAS Registry Number.
61671-80-5Relevant articles and documents
General preparative synthesis of 2'-O-methylpyrimidine ribonucleosides
Ross,Springer,Vasquez,Andrews,Cook,Acevedo
, p. 765 - 769 (2007/10/02)
A convergent and general approach to synthesizing 2'-O-methylpyrimidine ribonucleosides 4a-e-, 6, 7 on a multigram scale is described which begins with an improved procedure for making larger quantities of 2-O-methyl-1,3,5-tri-O-benzoyl-α-D-ribose. The sugar was reacted with the desired silylated pyrimidines at room temperature under Vorbruggen conditions. The crude products contained less than 10% of the α anomers and the desired β anomers were isolated by crystallization. The blocked nucleosides were then deprotected and isolated by standard methods.
