61672-52-4

Basic information

• Product Name: Isoquinoline, 5-(phenylmethoxy)-
• CAS NO: 61672-52-4
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Mol File: 61672-52-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 5-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 5-(phenylmethoxy)-(61672-52-4)
• EPA Substance Registry System: Isoquinoline, 5-(phenylmethoxy)-(61672-52-4)

Safety Data

• Hazardous Substances Data: 61672-52-4(Hazardous Substances Data)

Upstream product

• 34784-04-8 5-bromoisoquinoline 
• 100-51-6 benzyl alcohol 
• 2439-04-5 5-hydroxyisoquinoline 
• 586-98-1 2-Hydroxymethylpyridine 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Oxalic Diamides and tert-Butoxide: Two Types of Ligands Enabling Practical Access to Alkyl Aryl Ethers via Cu-Catalyzed Coupling Reaction

A robust and practical protocol for preparing alkyl aryl ethers has been developed, which relies on using two types of ligands to promote Cu-catalyzed alkoxylation of (hetero)aryl halides. The reaction scope is very general for a variety of coupling partners, particularly for challenging secondary alcohols and (hetero)aryl chlorides. In case of coupling with aryl chlorides and bromides, two oxalic diamides serve as the powerful ligands. The tert-butoxide is first demonstrated as a ligand for Cu-catalyzed coupling reaction, leading to alkoxylation of aryl iodides complete at room temperature. Additionally, a number of carbohydrate derivatives are applicable for this coupling reaction, affording the corresponding carbohydrate-aryl ethers in 29-98% yields.

Selectivity of N-versus O-alkylation in Mitsunobu reactions with various quinolinols and isoquinolinols

Reacting quinolinols and isoquinolinols under Mitsunobu conditions can give rise to N-alkylated products in addition to the normally desired O-alkylated structures. An in-depth study of how the solvent, reagent equivalents, position of the quinoline/isoqu

C-O cross-coupling of activated aryl and heteroaryl halides with aliphatic alcohols

A robust and general catalyst system facilitates the alkoxylation of activated heteroaryl halides with primary, secondary, and select tertiary alcohols without the need for an excess of either coupling partner (see scheme). This catalyst system displays broad functional-group tolerance and excellent regioselectivity, and is insensitive to the order of reagent addition. Copyright