616897-44-0

Basic information

• Product Name: 2-(1-benzylpiperidin-4-ylidene)malononitrile
• Synonyms: 2-(1-benzylpiperidin-4-ylidene)malononitrile
• CAS NO: 616897-44-0
• Molecular Weight: 237.304
• Mol File: 616897-44-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(1-benzylpiperidin-4-ylidene)malononitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-benzylpiperidin-4-ylidene)malononitrile(616897-44-0)
• EPA Substance Registry System: 2-(1-benzylpiperidin-4-ylidene)malononitrile(616897-44-0)

Safety Data

• Hazardous Substances Data: 616897-44-0(Hazardous Substances Data)

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 109-77-3 malononitrile 

Downstream Products

• 67686-01-5 1-benzyl-4-piperidinemethanol 
• 1463-52-1 ethyl 2-(1-benzylpiperidin-4-ylidene)-2-cyanoacetate 
• 743417-80-3 methyl N-benzyl-piperidin-4-yl-cyanoacetate 
• 99944-02-2 2-(1-benzylpiperidin-4-yl)acetic acid hydrochloride 
• 76876-70-5 N-benzyl-4-(2-hydroxyethyl)piperidine 
• 146495-13-8 α-cyano-(N-benzyl-piperidin-4-yl)-acetamide 
• 757236-88-7 {[2-(1-benzyl-piperidin-4-yl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 757236-89-8 2-amino-N-[2-(1-benzyl-piperidin-4-yl)-ethyl]-acetamide 

Relevant articles and documents

Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease

Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's Disease were assayed. The optimum hybrid inhibitor 3 is much more potent and selective than tacrine in vitro. Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro.

Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors

Abstract Some novel coumarin-3-carboxamide derivatives linked to N-benzylpiperidine scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. The screening results showed that most of compounds exhibited potent anti-AChE activity in the range of nM concentrations. Among them, compound 10c bearing an N-ethylcarboxamide linker and a 6-nitro substituent showed the most potent activity (IC50 = 0.3 nM) and the highest selectivity (SI = 26,300). Compound 10c was 46-fold more potent than standard drug donepezil against AChE. The kinetic study revealed that compound 10c exhibited mixed-type inhibition against AChE. Protein-ligand docking study demonstrated that the target compounds have dual binding site interaction mode and these results are in agreement with kinetic study.