61751-36-8

Basic information

• Product Name: Cyclopropanecarboxylic acid, 2,2-dimethyl-3-phenyl-, ethyl ester
• CAS NO: 61751-36-8
• Molecular Formula: C14H18O2
• Molecular Weight: 218.296
• Mol File: 61751-36-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Cyclopropanecarboxylic acid, 2,2-dimethyl-3-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 2,2-dimethyl-3-phenyl-, ethyl ester(61751-36-8)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 2,2-dimethyl-3-phenyl-, ethyl ester(61751-36-8)

Safety Data

• Hazardous Substances Data: 61751-36-8(Hazardous Substances Data)

Upstream product

• 5281-20-9 acetone hydrazone 
• 623-73-4 diazoacetic acid ethyl ester 
• 768-49-0 (2-methyl-1-propenyl)-benzene 
• 126087-62-5 (E)-ethyl 3-phenyl-2-(phenylsulfonyl)acrylate 
• 126087-64-7 1-Benzenesulfonyl-2,2-dimethyl-3-phenyl-cyclopropanecarboxylic acid ethyl ester 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 24470-78-8 isopropyltriphenylphosphonium iodide 
• 100-52-7 benzaldehyde 
• 4192-77-2 ethyl cinnamate 
• 13133-96-5 4-hydroxy-4-methyl-3-phenylpentanoic acid γ-lactone 
• 64-17-5 ethanol 
• 126113-01-7 (2S,3R)-2-Benzenesulfonyl-4-methyl-4-nitro-3-phenyl-pentanoic acid ethyl ester 

Downstream Products

• 50672-13-4 2,2-Dimethyl-3-phenyl-cyclopropan-carbonsaeure-⁽¹⁾ 
• 157240-02-3 methyl (1S,3S)-2,2-dimethyl-3-phenylcyclopropanecarboxylate 
• 50672-13-4 (±)-trans-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid 
• 51974-64-2 (±)-trans-(2,2-dimethyl-3-phenylcyclopropyl)methanol 
• 4489-17-2 (+/-)-2,2-dimethyl-3t-phenyl-cyclopropane-r-carbonyl chloride 
• 494846-26-3 (+)-trans-(1R,3R)-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid 
• 494846-57-0 (-)-trans-(1S,3S)-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid 
• 1557243-20-5 (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide 
• 1610023-35-2 C₁₂H₁₃ClO 
• 78003-28-8 trans-2,2-Dimethyl-3-(4-brom-phenyl)-cyclopropan-carbonsaeure-⁽¹⁾ 

Relevant articles and documents

Cycloaddition Reactions of Alkene Radical Cations using Iron(III)-Phenanthroline Complex

Single electron oxidation of electron-rich alkenes using the iron(III)-phenanthroline complex produced electrophilic alkene radical cations, which promoted efficient radical cation [2+1] cycloaddition reactions with diazo compounds. Subsequent chain propagation afforded tri- and tetra-substituted cyclopropanes. This methodology was also expanded to [3+2] cycloaddition reactions with vinyl diazoesters, validating this sustainable, first-row transition metal iron system for the single electron redox reactions. (Figure presented.).

α7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF-I

The present invention relates to chemical compounds of formula (I), with the substituents as described in the specification, useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7 nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also neuropathic pain and inflammatory diseases.

A general stereoselective method for the synthesis of cyclopropanecarboxylates. A new version of the homologous Horner-Wadsworth- Emmons reaction

The synthesis of α-, β- and γ-substituted α-phosphono-γ-lactones was accomplished using different ring closure and ring homologation strategies. It was found that the lactones could be selectively transformed into the corresponding ethyl cyclopropanecarboxylates by treatment with sodium ethoxide in boiling THF. The reported reaction provides an attractive alternative to the classical homologous Horner-Wadsworth-Emmons approach to the construction of cyclopropanes with electron-withdrawing functionalities. This journal is The Royal Society of Chemistry.