61781-58-6Relevant articles and documents
Homoserine and Threonine Peptide Assembly
Pirrung, Michael C.,Bakas, Nicole A.
supporting information, p. 238 - 242 (2017/11/03)
Drawing on our recent success with reagent-less peptide-bond formation through serine-based assembly reactions in organic solvent, their range has been expanded to threonine and homoserine (an aspartic acid precursor) in the N -terminal peptide. Amino aci
Methods of modifying N-termini of a peptide or protein using transferases
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Page/Page column 20; 21, (2016/08/03)
The invention includes a selective method of modifying the N-terminus of a protein using an aminoacyl tRNA transferase. In certain embodiments, the method comprises contacting a solution of the protein or peptide with a transferase and a derivative of a molecule, whereby the N-terminus of the protein or peptide is derivatized with the molecule.
The BF3·OEt2-assisted conversion of nitriles into thioamides with Lawesson's reagent
Nagl, Michael,Panuschka, Claudia,Barta, Andrea,Schmid, Walther
experimental part, p. 4012 - 4018 (2009/05/27)
A method for the thiolysis of nitriles by applying Lawesson's reagent and facilitated by the addition of boron trifluoride-diethyl ether complex is reported. The method opens an easy access to primary thioamides. Aromatic, benzylic, and aliphatic nitriles were converted into the corresponding thioamides in high to quantitative yields (even in unfavorable cases, e.g., ortho-substitut-ed benzonitriles). The reaction was performed in 1,2-dimethoxyethane-tetrahydrofuran or toluene-diethyl ether solvent mixtures at 20-50°C, and exhibited considerable selectivity in the case of multifunctional nitrile substrates, such as cyanomethyl N-acetylphenylalaninate, benzoylacetonitrile, 4-cyanobenzamide, 4-acetylbenzonitrile, or pent-3-enenitrile. Georg Thieme Verlag Stuttgart.