618-11-1

Basic information

• Product Name: α,α-dimethyl-3-(trifluoromethyl)benzenemethanol
• Synonyms: α,α-dimethyl-3-(trifluoromethyl)benzenemethanol
• CAS NO: 618-11-1
• Molecular Weight: 204.192
• Mol File: 618-11-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: α,α-dimethyl-3-(trifluoromethyl)benzenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: α,α-dimethyl-3-(trifluoromethyl)benzenemethanol(618-11-1)
• EPA Substance Registry System: α,α-dimethyl-3-(trifluoromethyl)benzenemethanol(618-11-1)

Safety Data

• Hazardous Substances Data: 618-11-1(Hazardous Substances Data)

Upstream product

• 917-64-6 methyl magnesium iodide 
• 2557-13-3 3-trifluoromethylbenzoic acid methyl ester 
• 67-64-1 acetone 
• 402-26-6 3-(trifluoromethyl)phenylmagnesium bromide 
• 349-76-8 3'-(trifluoromethyl)acetophenone 

Downstream Products

• 840-93-7 N-[1-methyl-1-(3-trifluoromethyl-phenyl)-ethyl]-acrylamide 
• 90862-10-5 Phenyl-carbamic acid 1-methyl-1-(3-trifluoromethyl-phenyl)-ethyl ester 
• 1599-13-9 1,4,5,6,7,7-hexachloro-norborn-5-ene-2-carboxylic acid-[1-methyl-1-(3-trifluoromethyl-phenyl)-ethylamide] 
• 2924-88-1 1-(α-chloro-isopropyl)-3-trifluoromethyl-benzene 
• 368-79-6 2-<3-(Trifluoromethyl)phenyl>propene 

Relevant articles and documents

Carbocation-forming reactions in ionic liquids

A number of trifluoroacetates, mesylates, and triflates have been studied in ionic liquids. Several lines of evidence indicate that all of these substrates react via ionization to give carbocationic intermediates. For example, cumyl trifluoroacetates give mainly the elimination products, but the Hammett ρ+ value of -3.74 is consistent with a carbocationic process. The analogous exo-2-phenyl-endo-3-deutero-endo-bicyclo-[2.2.1]hept-2-yl trifluoroacetate gives an elimination where loss of the exo-hydrogen occurs from a cationic intermediate. 1-Adamantyl mesylate and 2-adamantyl triflate react to give simple substitution products derived from capture of 1- and 2-adamantyl carbocations by the residual water in the ionic liquid. The triflate derivative of pivaloin, trans-2-phenylcyclopropylcarbinyl mesylate, 2,2-dimethoxycyclobutyl triflate, the mesylate derivative of diethyl (phenylhydroxymethyl)-thiophosphonate, and Z-1-phenyl-5-trimethylsilyl-3-penten- 1-yl trifluoroacetate all give products derived carbocation rearrangements (kΔ processes), anti-7-Norbornenyl mesylate gives products with complete retention of configuration, indicative of involvement of the delocalized 7-norbornenyl cation. 1,6-Methano[10]annulen-11-yl triflate reacts in [BMIM][NTf2] to give 1,6-methano[10]annulen-11-ol, along with naphthalene, an oxidized product derived from loss of trifluoromethanesulfinate ion. Analogous loss of CF3SO2- can be seen in reaction of PhCH(CF3)OTf. Ionic liquids are therefore viable solvents for formation of carbocationic intermediates via kc and k Δ processes.

ADDITIONS OF SUBSTITUTED PHENYLTHIYL RADICALS TO SUBSTITUTED α-METHYLSTYRENES. GROUND STATE AND TRANSITION STATE ELECTRONIC EFFECTS

The radical addition of substituted thiophenols to α-methylstyrene and substituted α-methylstyrenes has been investigated at 70 deg C.Relative reactivities of pairs of thiophenols competing with individual alkenes can be utilized to obtain Hammett correlations.The interplay of substituent effects in alkene and thiyl radical leads to examples of non-linear rho values.Rationales for this behavior will be offered in terms of variable contributions from ground state and transition state electronic factors as well as in terms of possible mechanistic changes.