61849-14-7

Basic information

• Product Name: PROSTACYCLIN SODIUM SALT
• Synonyms: EPOPROSTENOL;EPOPROSTENOL SODIUM;EPOPROSTENOL SODIUM SALT;(5-Z)-9-DEOXY-6,9ALPHA-EPOXY-PGF1ALPHA, SODIUM SALT;[5Z,9ALPHA,11ALPHA,13E,15S]-6,9-EPOXY-11,15-DIHYDROXYPROSTA-5,13-DIEN-1-OIC ACID SODIUM SALT;6,9ALPHA-EPOXY-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, SODIUM SALT;PROSTACYCLINE SODIUM SALT;PROSTACYCLIN SODIUM SALT
• CAS NO: 61849-14-7
• Molecular Formula: C20H31NaO5
• Molecular Weight: 374.45
• EINECS: 234-237-8
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 61849-14-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 168-170 °C
• Boiling Point: 530.2 °C at 760 mmHg
• Flash Point: 182.1 °C
• Appearance: white/powder
• Vapor Pressure: 1.86E-13mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: H2O: 1 mg/mL Hydrolyzes to 6-ketoprostaglandin F1α in
• Sensitive: Moisture Sensitive
• Stability: Light Sensitive, Temperature Sensitive
• Merck: 13,7967
• BRN: 6472195
• CAS DataBase Reference: PROSTACYCLIN SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: PROSTACYCLIN SODIUM SALT(61849-14-7)
• EPA Substance Registry System: PROSTACYCLIN SODIUM SALT(61849-14-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 22-26-36
• WGK Germany: 3
• RTECS: UK8008700
• F: 3-10
• Hazardous Substances Data: 61849-14-7(Hazardous Substances Data)

Usage

Description

Prostacyclin sodium salt, also known as Epoprostenol sodium salt, is a synthetic analog of the naturally occurring prostaglandin PGI2. It is a potent vasodilator and inhibitor of platelet aggregation, making it a valuable compound in various medical applications.
Used in Cardiovascular Applications:
Prostacyclin sodium salt is used as a vasodilator for the treatment of pulmonary arterial hypertension. It helps to relax the blood vessels, improving blood flow and reducing the workload on the heart.
Used in Hematology Applications:
Prostacyclin sodium salt is used as an antiplatelet agent to prevent platelet aggregation and the formation of blood clots. It is particularly useful in patients with cardiovascular disorders or those undergoing procedures that may increase the risk of clot formation.
Used in Platelet Preparation:
Prostacyclin sodium salt is used as a supplement in platelet-rich-plasma and for platelet preparation to prevent platelet activation and aggregation during the process.
Used in Platelet Washing Procedure:
Prostacyclin sodium salt is used in the preparation of stock solutions for platelet washing procedures, ensuring the preservation of platelet function and preventing platelet damage during the washing process.
Overall, Prostacyclin sodium salt is a versatile compound with significant applications in the medical field, particularly in cardiovascular and hematology applications, as well as in platelet preparation and washing procedures.

Biological Activity

Epoprostenol is a potent agonist at IP prostanoid receptors. Inhibits platelet aggregation and induces vasodilation.

Biochem/physiol Actions

Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

InChI:InChI=1/C20H32O5.Na/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22;/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,15-8u;/t14-,16+,17+,18+,19-;/m0./s1