61860-50-2

Basic information

• Product Name: 1-Indolizinecarboxylic acid, 3-acetyl-2-phenyl-, methyl ester
• CAS NO: 61860-50-2
• Molecular Formula: C18H15NO3
• Molecular Weight: 293.322
• Mol File: 61860-50-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Indolizinecarboxylic acid, 3-acetyl-2-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Indolizinecarboxylic acid, 3-acetyl-2-phenyl-, methyl ester(61860-50-2)
• EPA Substance Registry System: 1-Indolizinecarboxylic acid, 3-acetyl-2-phenyl-, methyl ester(61860-50-2)

Safety Data

• Hazardous Substances Data: 61860-50-2(Hazardous Substances Data)

Upstream product

• 17282-41-6 N-acetonylpyridinium bromide 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 110-86-1 pyridine 

Relevant articles and documents

Indolizines 4. The synthesis of new 3-vinylindolizines.

New 3-vinylindolizines have been synthesized by two methods.The first strategy calls for the Wittig olefination of 3-acylindolizines with methylenetriphenylphosphorane or methoxymethylenetriphenylphosphorane.The best yields are obtained when the ylid is formed at room temperature and the condensation in refluxing THF.The required 3-acylindolizines were obtained by direct acylation of indolizines or by 1,3-dipolar cyclo-additions to acylmethylpyridinium ylids.The following 3-isopropenylindolizines were made with good yields: unsubstituted (18, 85percent), 2-methyl (10, 98percent), 2-C6H5 (17, 95percent), 1-COOMe (20, 98percent), 1-COOMe-2-C6H5 (22, 91 percent), 1,2-di-COOMe (24, 58percent).Also synthesized are the following 3-α-styrylindolizines: 2-C6H5 (19, 99percent), 1-COOMe (21, 93percent), 1-COOMe-2-C6H5 (23, 87percent), 1,2-diCOOMe (25, 66percent). 3-(α-Methyl-β-methoxyvinyl)indolizines E (26, 40percent) and Z (27, 40percent) were also obtained.The second strategy involves the 1,3-dipolar cyclo-addition of dipolarophiles to allylpyridinium ylids.The following new 3-vinylindolizines have been synthesized: 1-carbomethoxy-3-vinylindolizine (30, 21percent), 1,2-dicarbomethoxy-3-vinylindolizine (31, 16percent), 1-carbomethoxy-3-β-styrylindolizine (33, 43percent), 3-β-styrylindolizine (34, 17percent), 1-carbomethoxy-3-(β-carbomethoxy)vinylindolizine 38 (31percent).