61946-95-0

Basic information

• Product Name: 4-(tert-butyl)-N-hydroxybenzimidoyl chloride
• Synonyms: 4-(tert-butyl)-N-hydroxybenzimidoyl chloride
• CAS NO: 61946-95-0
• Molecular Weight: 211.691
• Mol File: 61946-95-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-(tert-butyl)-N-hydroxybenzimidoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(tert-butyl)-N-hydroxybenzimidoyl chloride(61946-95-0)
• EPA Substance Registry System: 4-(tert-butyl)-N-hydroxybenzimidoyl chloride(61946-95-0)

Safety Data

• Hazardous Substances Data: 61946-95-0(Hazardous Substances Data)

Upstream product

• 939-97-9 4-tert-Butylbenzaldehyde 
• 180261-48-7 4-tert-butyl benzene carbaldehyde oxime 

Downstream Products

• 86387-56-6 4-tert-Butyl-N-hydroxy-thiobenzimidic acid 2-diethylamino-ethyl ester; hydrochloride 
• 1203465-86-4 5-(bromomethyl)-3-(4-(tert-butyl)phenyl)isoxazole 

Relevant articles and documents

One-pot synthesis of (3-phenylisoxazol-5-yl) methanol derivatives under ultrasound

An ultrasonic-assisted, one-pot, efficient, convenient procedure for the synthesis of (3-phenylisoxazol-5-yl)methanol derivatives has been developed. (3-Phenylisoxazol-5-yl)-methanol derivatives with biological and pharmaceutical property have been synthe

Betulinic acid derivatives: a new class of α-glucosidase inhibitors and LPS-stimulated nitric oxide production inhibition on mouse macrophage RAW 264.7 cells

Chemical manipulation studies were conducted on betulinic acid (1), twenty-one new rationally designed analogues of 1 with modifications at C-28 were synthesized for their evaluation of inhibitory effects on α-glucosidase and LPS-stimulated nitric oxide production in mouse macrophage RAW 264.7 cells. Compound 2 (IC50 = 5.4 μM) exhibited an almost 1.4-fold increase in α-glucosidase inhibitory activity on yeast α-glucosidase while analogues 5 (IC50 16.4 μM) and 11 (IC50 16.6 μM) exhibited a 2-fold enhanced inhibitory activity on NO-production than betulinic acid.

A convenient synthesis of α-hydroxyiminoacetonitriles from aldoximes

Aromatic α-hydroxyiminoacetonitriles can be conveniently prepared by a facile one-pot procedure in high yields involving chlorination of the corresponding aldoximes with tert-butyl hypochlorite followed by reaction with alkali cyanide.