61977-29-5

Basic information

• Product Name: 6-CHLOROBENZO[D]ISOXAZOL-3-OL
• Synonyms: 6-CHLOROBENZO[D]ISOXAZOL-3-OL;6-CHLORO-3-HYDROXY-1,2-BENZISOXAZOLE;6-Chlorobenzo[d]isoxazol-3-ol 97%;6-CHLORO-3-HYDROXYBENZISOXAZOLE;6-Chloro-3-hydroxy-1,2-benzisoxazole 97%;6-Chloro-1,2-benzisoxazol-3-ol;6-Chloro-1,2-benzisoxazol-3-ol, 6-Chlorobenzo[d]isoxazol-3-ol;6-Chloro-1,2-benzisoxazol-3(2H)-one
• CAS NO: 61977-29-5
• Molecular Formula: C₇H₄ClNO₂
• Molecular Weight: 169.57
• Mol File: 61977-29-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 218-220°C
• Boiling Point: 336.7 °C at 760 mmHg
• Flash Point: 157.4 °C
• Appearance: white to beige/
• Density: 1.486 g/cm³
• Vapor Pressure: 5.65E-05mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: room temp
• Solubility: DMSO: soluble15mg/mL (clear solution)
• PKA: 13.14±0.20(Predicted)
• CAS DataBase Reference: 6-CHLOROBENZO[D]ISOXAZOL-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLOROBENZO[D]ISOXAZOL-3-OL(61977-29-5)
• EPA Substance Registry System: 6-CHLOROBENZO[D]ISOXAZOL-3-OL(61977-29-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22-41-37/38
• Safety Statements: 26-36/37/39-39
• Hazardous Substances Data: 61977-29-5(Hazardous Substances Data)

Usage

Chemical Properties

gray solid

Uses

6-Chloro-1,2-benzisoxazol-3(2H)-one is a D-amino acid oxidase reversible inhibitor.

InChI:InChI=1/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)

Upstream product

• 61799-78-8 4-chloro-2,N-dihydroxy-benzamide 
• 61799-78-8 4-chloro-N,2-dihydroxybenzamide 
• 530-62-1 1,1'-carbonyldiimidazole 
• 22717-55-1 methyl 4-chloro-2-hydroxybenzoate 
• 5106-98-9 4-chlorosalicylic acid 

Downstream Products

• 16263-54-0 3,6-dichlorobenzisoxazole 
• 1072903-41-3 6-chloro-3-methoxy-benzo[d]isoxazole 

Relevant articles and documents

Chromatography-free, Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids to 3-hydroxybenzisoxazoles

The Mitsunobu reaction has become one of the most powerful tools to alkylate acidic pronucleophiles. A significant caveat of Mitsunobu chemistry, however, is that the reaction mixture is often plagued with purification problems owing to the phosphine oxide and hydrazine dicarboxylate by-products. In addition to the development of more readily separable Mitsunobu reagents, the product's physicochemical properties may be exploited to facilitate purification. In this regard, we present a swift and efficient preparation of 3-hydroxybenzisoxazoles by the Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids, which can be isolated by an acid–base work-up. As expected, a range of functional groups was compatible with the chemistry.

ARALKYL SUBSTITUTED PIPERIDINE OR PIPERAZINE DERIVATIVES AND THEIR USE FOR TREATING SCHIZOPHRENIA

The present invention discloses an aralkyl substituted piperidine or piperazine derivative and the use of the derivative in preparation of medicaments for treating schizophrenia and correlative psychoneuroses. It is shown by pharmacological tests that the derivative of the present invention has better antischizophrenic effect and less toxicity. Said derivative is a free base or salt of the compound having the following general formula.

Substituted benzisoxazole and benzisothiazole herbicidal agents

There are provided substituted benzisoxazole and benzisothiazole compounds having the structural formula I STR1 Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.